{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:05:06Z","timestamp":1772233506201,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Among different coronary stents implanted in High Bleeding Risk (HBR) patients with an indication for short antiplatelet therapy, no comparisons in terms of efficacy have been provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Network Meta Analysis was performed including all randomized controlled trials comparing different coronary stents evaluated in HBR patients. Major Adverse Cardiovascular Events (MACEs) as defined by each included trial were the primary end point, whereas TLR (target lesion revascularization), TVR (target vessel revascularization), stent thrombosis and total and major (BARC3\u20105) bleedings were the secondary ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of four studies (ONYX ONE, LEADERS FREE, SENIOR and HBR in BIO\u2010RESORT) including 6637 patients were analyzed with different kind of stents and dual antiplatelet therapy (DAPT) length (1 or 6 months) on 12 months follow\u2010up. About one\u2010third of these patients were defined HBR due to indication for oral anticoagulation. All drug eluting stents (DESs) reduced risk of MACE compared to Bare Metal Stents (BMSs) when followed by a 1\u2010month DAPT. At SUCRA analysis, Orsiro was the device with the highest probability of performing best. Rates of TLR and TVR were significantly lower when using Resolute Onyx, Synergy and BioFreedom stents in comparison to BMS when followed by 1\u2010month DAPT, with Synergy ranking best. Synergy also showed a significantly lower number of stent thrombosis compared to BMS (RR 0.28, 95%\u00a0CI 0.06\u22120.93), while Orsiro and Resolute Integrity showed the highest probability of performing best.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In HBRs patients, all DESs were superior to BMSs in terms of efficacy and safety. Among DESs, Orsiro was the one with the highest ranking in terms of MACE, mainly driven by a reduced incidence of repeated revascularization and stent thrombosis<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31047","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T05:30:33Z","timestamp":1713504633000},"page":"843-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of drug\u2010eluting stents for patients at high risk of bleedings: A network meta\u2010analysis"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-4300","authenticated-orcid":false,"given":"Federico","family":"Giacobbe","sequence":"first","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"},{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-214X","authenticated-orcid":false,"given":"Eduardo","family":"Valente","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"},{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Morena","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"},{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Nebiolo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"},{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Giannino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"},{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-9501","authenticated-orcid":false,"given":"Ovidio","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bruno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Isaevska","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Richiardi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-3918","authenticated-orcid":false,"given":"Mario","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, San Giovanni Bosco Hospital ASL Citt\u00e0 di Torino Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-8510","authenticated-orcid":false,"given":"Giuseppe Biondi","family":"Zoccai","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Biotechnologies Sapienza University Latina Italy"},{"name":"Mediterranea Cardiocentro Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-9401","authenticated-orcid":false,"given":"Francesco","family":"Burzotta","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Fondazione Policlinico Universitario A. 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