{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T07:17:18Z","timestamp":1758093438656,"version":"3.44.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008645","name":"Terumo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ethylene diamine tetra\u2010acetic acid (EDTA) is a chelating agent used to dissolve calcium deposits but evidence in decalcifying atherosclerotic lesions is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We assessed the feasibility and efficacy of EDTA delivered via porous balloon to target calcified lesions in cadaveric below\u2010the\u2010knee (BTK) arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using porcine carotid arteries, EDTA concentration was measured in the arterial wall and outside the artery at the 0\u2010, 0.5\u2010, 4\u2010, and 24\u2010h circulation after the injection through a porous balloon. In cadaver BTK samples, the proximal and distal anterior tibial artery (ATA) and distal posterior tibial artery (PTA) were studied. EDTA\u20102Na\/H2O or EDTA\u20103Na\/H2O were administrated using a porous balloon, then circulated for 6 h for EDTA\u20103Na\/H2O and 24 h for EDTA\u20102Na\/H2O and EDTA\u20103Na\/H2O. Micro\u2010CT imaging of the artery segments before and after the circulation and cross\u2010sectional analyses were performed to evaluate calcium burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the porcine carotid study, EDTA was delivered through a porous balloon present in the arterial wall and was retained there for 24 h. In BTK arteries, cross\u2010sectional analyses of micro\u2010CT revealed a significant decrease in the calcium area in the distal ATA segment under 24\u2010h circulation with EDTA\u20102Na\/H2O and in the distal ATA segment under 24\u2010h circulation with EDTA\u20103Na\/H2O. The proximal ATA segment under 6\u2010h circulation with EDTA\u20103Na\/H2O showed no significant change in any parameters of calcium<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EDTA\u20103Na\/H2O or EDTA\u20102Na\/H2O with longer circulation times resulted in greater calcium reduction in atherosclerotic lesion. EDTA may have a potential therapeutic option for the treatment of atherosclerotic calcified lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31052","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T04:00:01Z","timestamp":1712894401000},"page":"972-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of EDTA with porous balloon on calcified lesion: An atherosclerotic cadaver study"],"prefix":"10.1002","volume":"103","author":[{"given":"Kenji","family":"Kawai","sequence":"first","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Madra","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Kawakami","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sato","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Konishi","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Shiraki","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Sekimoto","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-0015","authenticated-orcid":false,"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-0184","authenticated-orcid":false,"given":"Aloke V.","family":"Finn","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg MD USA"},{"name":"University of Maryland School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-022-00885-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008434"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.603"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1894389"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01486-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.06.021"},{"volume-title":"A Textbook on EDTA Chelation Therapy","year":"2001","author":"Cranton EM","key":"e_1_2_10_9_1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2004.06.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:83:3:207"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2023.01.003"},{"issue":"8","key":"e_1_2_10_15_1","article-title":"Part 8: advanced challenges in resuscitation: section 1: life\u2010threatening electrolyte abnormalities. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation","volume":"102","author":"Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","year":"2000","journal-title":"Circulation"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-013-0347-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(88)90082-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.107548"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03156.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000663"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb00533.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.3.1194"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2019.04.005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010774"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1583\/12-4149MR.1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280807"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-6864-5.00017-7"},{"issue":"8","key":"e_1_2_10_29_1","first-page":"204","article-title":"Deaths associated with hypocalcemia from chelation therapy\u2010\u2010Texas, Pennsylvania, and Oregon, 2003\u20102005","volume":"55","author":"Centers for Disease Control and Prevention","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:47:50Z","timestamp":1758008870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ccd.31052"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31052","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2024,4,12]]},"assertion":[{"value":"2024-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}