{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:10:15Z","timestamp":1740103815918,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The clinical efficacy and safety of a novel left atrial appendage (LAA) occluder of the SeaLA closure system in patients with nonvalvular atrial fibrillation (NVAF) were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with NVAF are at a higher risk of stroke compared to healthy individuals. Left atrial appendage closure (LAAC) has emerged as a prominent strategy for reducing the risk of thrombosis in individuals with NVAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multicenter study was conducted in NVAF patients with a high risk of stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LAAC was successfully performed in 163 patients. The mean age was 66.93\u2009\u00b1\u20097.92 years, with a mean preoperative CHA2DS2\u2010VASc score of 4.17\u2009\u00b1\u20091.48. One patient with residual flow &gt;3\u2009mm was observed at the 6\u2010month follow\u2010up, confirmed by TEE. During the follow\u2010up, 2 severe pericardiac effusions were noted, and 2 ischemic strokes were observed. Four device\u2010related thromboses were resolved after anticoagulation treatment. There was no device embolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The LAAC with the SeaLA device demonstrates encouraging feasibility, safety, and efficacy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31056","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T09:10:14Z","timestamp":1717665014000},"page":"1491-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Percutaneous left atrial appendage closure with SeaLA device in non\u2010valvular atrial fibrillation"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0364-8736","authenticated-orcid":false,"given":"Zulu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command Shenyang 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