{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:10:20Z","timestamp":1740103820305,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During the transition from dual antiplatelet therapy (DAPT) to single antiplatelet therapy (SAPT), previous studies have raised concerns about a rebound effect. We compared platelet and inflammatory cell adhesion on different types of stents in the setting of clopidogrel presence and withdrawal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In Experiment 1, three pigs were administered with DAPT, that is, clopidogrel and acetylsalicylic acid (ASA), for 7 days. Each animal underwent an extracorporeal carotid arteriovenous shunt model implanted with fluoropolymer\u2010coated everolimus\u2010eluting stent (FP\u2010EES), biodegradable\u2010polymer sirolimus\u2010eluting stent (BP\u2010SES), and biodegradable\u2010polymer everolimus\u2010eluting stents (BP\u2010EES). In Experiment 2, two pigs were administered DAPT, clopidogrel was then withdrawn at day 7, and SAPT with ASA was continued for next 21 days. Then flow\u2010loop experiments with the drawn blood from each time point were performed for FP\u2010EES, BioLinx\u2010polymer zotarolimus\u2010eluting stents (BL\u2010ZES), and BP\u2010EES. The rebound effect was defined as the statistical increase of inflammation and platelet adhesion assessed with immunohistochemistry on the stent\u2010strut level basis from baseline to day\u201014 or 28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both experiments showed platelet adhesion value was highest in BP\u2010EES, while the least in FP\u2010EES during DAPT therapy. There was no increase in platelet or inflammatory cell adhesion above baseline values (i.e., no therapy) due to the cessation of clopidogrel on the stent\u2010strut level. Monocyte adhesion was the least for FP\u2010EES with the same trend observed for neutrophil adhesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No evidence of rebound effect was seen after the transition from DAPT to SAPT. FP\u2010EES demonstrated the most favorable antithrombotic and anti\u2010inflammatory profile regardless of the different experimental designs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31083","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T05:24:54Z","timestamp":1716269094000},"page":"10-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of thrombogenicity in different types of drug\u2010eluting stents during transition from DAPT to SAPT"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-9508","authenticated-orcid":false,"given":"Kenji","family":"Kawai","sequence":"first","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-1243","authenticated-orcid":false,"given":"Yu","family":"Sato","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank D.","family":"Kolodgie","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-6971","authenticated-orcid":false,"given":"Rika","family":"Kawakami","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Konishi","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-4557","authenticated-orcid":false,"given":"Laura E. L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-0015","authenticated-orcid":false,"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-0184","authenticated-orcid":false,"given":"Aloke V.","family":"Finn","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc. Gaithersburg Maryland"},{"name":"University of Maryland Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1323"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8145"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31858-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8146"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.09.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7580"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.086"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351144"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.026"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024835"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.5.532"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098615588085"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-08-0554"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.937961"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.03.029"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00938"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00728"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.06.034"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00740"},{"issue":"2","key":"e_1_2_10_23_1","first-page":"15","article-title":"Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic response in healthy subjects","volume":"25","author":"Savcic M","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.03.023"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.11.030"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.06.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.038"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0652-z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.5244"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00135"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1116\/1.4944586"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2017.1386098"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.07.016"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.2.133"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T15:22:22Z","timestamp":1720797742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ccd.31083"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31083","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"2023-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}