{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:10:14Z","timestamp":1768317014792,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Challenging anatomies and comorbidities have impact on success in transcatheter aortic valve replacement (TAVR). There is controversy whether the extent of the aortic angle (AA) has an impact on procedural outcomes. Matched comparative outcome data of new generation transcatheter heart valves (THVs) in horizontal aorta (HA) are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1582 patients with severe native aortic stenosis (AS) treated with the SAPIEN3 <jats:italic>Ultra<\/jats:italic> (Ultra; <jats:italic>n<\/jats:italic>\u2009=\u2009526) or ACURATE <jats:italic>Neo2<\/jats:italic> (Neo2; <jats:italic>n<\/jats:italic>\u2009=\u20091056) THVs from January 2017 to January 2023 were analyzed. Patients with non\u2010horizontal aortas (AA\u2009&lt;\u200951.7\u00b0, <jats:italic>n<\/jats:italic>\u2009=\u2009841) were excluded. The population was matched by 1\u2010to\u20101 nearest\u2010neighbor matching (Ultra, <jats:italic>n<\/jats:italic>\u2009=\u2009246; Neo2, <jats:italic>n<\/jats:italic>\u2009=\u2009246). Clinical and procedural outcome were evaluated according to VARC\u20103 recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Technical success (93.1% vs. 94.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.572) was high after Ultra and Neo2. Device success (80.5% vs. 89.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.05) was inferior with Ultra. Neo2 reveals superior hemodynamic properties with lower rate of severe prosthesis patient mismatch (12.0% vs. 3.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and elevated gradients (20\u2009mmHg: 11.9% vs. 1.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Ultra showed a lower rate of relevant paravalvular regurgitation (mild paravalvular regurgitation or Valve\u2010in\u2010Valve due to paravalvular regurgitation: 0.0% vs. 3.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). The rate of procedural bailout maneuvers (0.8% vs. 0.4%, <jats:italic>p<\/jats:italic>\u2009=\u20091.000) and thirty\u2010day all\u2010cause mortality (1.3% vs. 2.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.496) was similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transfemoral TAVR in patients with severe aortic stenosis and HA, using the balloon expandable Sapien3 Ultra and self\u2010expanding ACURATE Neo2 prosthesis, is feasible and safe. Therefore, valve selection between these platforms should be made irrespective of the aortic angle by a team experienced with both valves based on their specific advantages. Large, randomized trials in this sub\u2010group of patients would be necessary to compare long term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31094","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:00:21Z","timestamp":1718128821000},"page":"591-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of transfemoral TAVR using two new\u2010generation devices in patients with horizontal aorta"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-8096","authenticated-orcid":false,"given":"Clemens","family":"Eckel","sequence":"first","affiliation":[{"name":"Department of Cardiology St. Johannes Hospital Dortmund Germany"},{"name":"Carl von Ossietzky Universit\u00e4t Oldenburg, School VI, School of Medicine and Health Sciences Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-7478","authenticated-orcid":false,"given":"Won\u2010Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center Bad Nauheim Germany"},{"name":"Department of Cardiac Surgery Kerckhoff Heart Center Bad Nauheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Botros","family":"Wasif","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Johannes Hospital Dortmund Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Grothusen","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Johannes Hospital Dortmund Germany"},{"name":"Department of Cardiac Surgery University of Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Els\u00e4sser","sequence":"additional","affiliation":[{"name":"Carl von Ossietzky Universit\u00e4t Oldenburg, School VI, School of Medicine and Health Sciences Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Dohmen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery St. Johannes Hospital Dortmund Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstratios I.","family":"Charitos","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Kerckhoff Heart Center Bad Nauheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Sossalla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center Bad Nauheim Germany"},{"name":"Department of Cardiac Surgery Kerckhoff Heart Center Bad Nauheim 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