{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:08:43Z","timestamp":1791410923178,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with nonvalvular atrial fibrillation (AF) not suitable for long\u2010term anticoagulant therapy undergo percutaneous left atrial appendage closure (LAAC) using the WATCHMAN device. The safety and efficacy of WATCHMAN\u2010FLX (WM\u2010FLX) compared with WATCHMAN\u20102.5 (WM\u20102.5), particularly in Asian populations, is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the background, procedure, and clinical outcomes of 199 patients who underwent LAAC between September 2019 and December 2022 and compared WM\u20102.5 (72 patients) with WM\u2010FLX (127 patients).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 76 years, with 128 men, and 100 had nonparoxysmal AF (non\u2010PAF). The mean CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc, and HAS\u2010BLED were 5.1, and 3.2 points, respectively. WM\u2010FLX group demonstrated a shorter procedure time than WM\u20102.5 group (50 vs. 42\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The WM\u2010FLX group demonstrated no procedural\u2010related acute cardiac tamponade, which was significantly low (5.6% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and a significantly higher rate of complete seal at 45\u2010day (63% vs. 80%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). WM\u2010FLX group had a significantly higher cumulative 1\u2010year incidence of device\u2010related thrombosis (DRT) than WM\u20102.5 group (3.4% vs. 7.0%, Log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Univariate analysis identified two DRT risk factors in the WM\u2010FLX group: non\u2010PAF (odds ratio [OR] 7.72; 95% confidence interval [CI] 1.20\u201348.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and 35\u2010mm device (OR 5.13; 95% CI 1.31\u201319.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WM\u2010FLX significantly improved the procedural quality and safety of LAAC. However, DRT remains an important issue even in the novel LAAC device, being a hazard for patients with high DRT risk, such as having non\u2010PAF and using 35\u2010mm devices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31111","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:34:52Z","timestamp":1718771692000},"page":"318-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transition from WATCHMAN generation\u20102.5 device to WATCHMAN FLX device for percutaneous left atrial appendage closure: Incidence and predictors of device\u2010related thrombosis and short\u2010 to mid\u2010term outcomes"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7622-8494","authenticated-orcid":false,"given":"Ryuki","family":"Chatani","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tasaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nishiura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Mushiake","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Maruo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Kadota","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurashiki Central Hospital Kurashiki 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