{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:40:42Z","timestamp":1757612442276,"version":"3.44.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 5%\u221225% of non\u2010ST\u2010elevation acute coronary syndrome (NSTE\u2010ACS) patients, coronary angiography reveals no obstructive coronary arteries (MINOCA). Coronary microvascular disease (CMD) is a potential causal pathophysiological mechanism in these patients and can be diagnosed by continuous thermodilution assessment. Recently, the microvascular resistance reserve (MRR) has been introduced as a novel index to assess the vasodilatory capacity of the microcirculation. However, continuous thermodilution and MRR have never been investigated in the acute setting in MINOCA patients and invasive assessment of the microcirculation in these patients are currently lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objectives of the study were to investigate the incidence of CMD (MRR\u2009\u2264\u20092.7) in patients with MINOCA and to evaluate the feasibility and safety of continuous thermodilution\u2010based assessment during index coronary angiography in the acute setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a prospective, observational, pilot study investigating coronary physiology in the acute setting in MINOCA patients. Patients admitted with a diagnosis of NSTE\u2010ACS were eligible for inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 19 MINOCA patients were included in this analysis;\u00a0the mean age was 70\u2009\u00b1\u20099 years, and 79% were females. CMD was present in 6 patients (32%). Q<jats:sub>rest<\/jats:sub> was significantly higher in the MRR\u2009\u2264\u20092.7 group compared to the MRR\u2009&gt;\u20092.7 group (0.076 [0.057\u22120.100] vs. 0.049 [0.044\u22120.071] L\/min, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). R<jats:sub>\u00b5,rest<\/jats:sub> was significantly lower in the MRR\u2009\u2264\u20092.7 group compared to the MRR\u2009&gt;\u20092.7 group (1083 [710\u22121510] vs. 1563 [1298\u22121970]\u00a0WU,\u00a0<jats:italic>p<\/jats:italic>\u2009=\u20090.04). No periprocedural complications or hemodynamic instability have occurred during continuous thermodilution assessment during the index coronary angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients admitted for MINOCA undergoing immediate coronary angiography, continuous thermodilution assessment\u00a0and MRR are feasible and safe in the acute setting, and evidence of functional CMD could be observed in one\u2010third of the MINOCA patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31122","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:34:31Z","timestamp":1718771671000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Continuous thermodilution and microvascular resistance reserve during the index procedure in acute coronary syndrome without obstructive coronary artery disease: A pilot study"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-7108","authenticated-orcid":false,"given":"Jesse P. A.","family":"Demandt","sequence":"first","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-0796","authenticated-orcid":false,"given":"Mohamed","family":"El Farissi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemiek","family":"de Vos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-0999","authenticated-orcid":false,"given":"Rob","family":"Eerdekens","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Teeuwen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guus","family":"Brueren","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik M.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim A. L.","family":"Tonino","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven The Netherlands"},{"name":"Department of Biomedical Engineering Eindhoven University of Technology Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico H. 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