{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:01:28Z","timestamp":1769634088620,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiofrequency catheter ablation (RFCA) has emerged as a therapeutic option for surgical myectomy and alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM), but its efficacy remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Due to limited research on RFCA for HCM, there is an ongoing attempt to assess its efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Embase, and Scopus were systematically searched for studies assessing the efficacy outcomes for patients with HOCM who underwent RFCA. Mean differences (MDs) with 95% confidence intervals (CIs) were computed using a random\u2010effects model and heterogeneity was assessed using <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 11 studies comprising 470 patients, of whom 34.6% were female. The mean patient age ranged from 43.7 to 60.7 years. During the follow\u2010up after RFCA, there was a significant decrease in the left ventricular outflow tract (LVOT) gradient at rest (MD \u221260.25\u2009mmHg; 95% CI [\u221270.53;\u221259.14\u2009mmHg]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and during stimulation (MD \u221283.56\u2009mmHg; 95% CI [\u2212100.36;\u221266.76\u2009mmHg]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Moreover, RFCA reduced interventricular septum (IVS) thickness (MD \u22123.61\u2009mm; 95% CI [\u22125.64; \u22121.59\u2009mm]; <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and New York Heart Association (NYHA) class (MD \u22121.46; 95% CI [\u22121.69; \u22121.24]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with HOCM, RFCA was associated with an improved NYHA class, reduced IVS thickness, and decreased LVOT gradient at rest and with stimulation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31125","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T07:01:36Z","timestamp":1718953296000},"page":"1096-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Radiofrequency ablation in patients with obstructive hypertrophic cardiomyopathy: An updated comprehensive review and meta\u2010analysis"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-5206","authenticated-orcid":false,"suffix":"Jr.","given":"Antonio","family":"da Silva Menezes","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Medicine Faculty Federal University of Goi\u00e1s Goi\u00e1s Brazil"},{"name":"Clinical Medicine Department, Medical and Life School Pontifical Catholic University of Goi\u00e1s Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo R.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medicine Faculty Federal University of Goi\u00e1s Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernani","family":"de Oliveira Filho","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medicine Faculty Federal University of Goi\u00e1s Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias J. R.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medicine Faculty Federal University of Goi\u00e1s Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius M. R.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medicine Faculty Federal University of Goi\u00e1s Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor R. Y.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Clinical Medicine Department, Medical School Evangelical University of Goi\u00e1s Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guideline","volume":"142","author":"Ommen 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