{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:34:13Z","timestamp":1780436053609,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial appendage closure (LAAC) represents an alternative to oral anticoagulation for stroke prevention in patients with non\u2010valvular atrial fibrillation (AF). While transoesophageal echocardiography is the current standard for guiding LAAC procedures, several centers have employed fluoroscopic guidance alone. However, data on long\u2010term outcomes are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 536 patients with AF undergoing LAAC and with available data on long\u2010term follow\u2010up were included in the retrospective, single\u2010center analysis. Outcomes of patients undergoing fluoroscopy\u2010guided LAAC were compared with those undergoing echocardiography guided LAAC. Time\u2010dependent analysis was performed with the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 234 (44%) and 302 (56%) patients were treated with echocardiography and fluoroscopy guidance, respectively. Baseline characteristics did not differ between the two groups. Procedural success rates were high in both groups (97% of fluoroscopy vs. 98% of echocardiography guided procedures; <jats:italic>p<\/jats:italic>\u2009=\u20090.92) and rates of relevant peri\u2010device leaks (<jats:italic>p<\/jats:italic>\u2009=\u20090.50) and device\u2010related thrombus formation (<jats:italic>p<\/jats:italic>\u2009=\u20090.22) did not differ between groups. Median clinical follow\u2010up time was 48 (IQR 19\u201373) months. Rates of all\u2010cause mortality (<jats:italic>p<\/jats:italic>\u2009=\u20090.15, HR 0.83, CI 0.64\u20131.07) and stroke (<jats:italic>p<\/jats:italic>\u2009=\u20090.076, HR 2.23, CI 0.90\u20135.54) were comparable among groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LAAC with fluoroscopy guidance alone is equally safe and leads to similar clinical outcome compared to LAAC with additional echocardiography guidance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31126","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T02:54:53Z","timestamp":1718938493000},"page":"343-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term outcomes after echocardiography versus fluoroscopy\u2010guided left atrial appendage closure: Is there still a role for a simplified 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