{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:59:39Z","timestamp":1790369979856,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radial access is the default approach in interventional cardiology. The Axiostat\u00ae surgical hemostatic dressing, using chitosan as its active component, has demonstrated potential in accelerating blood clotting. This study aims to assess the efficacy and the safety of the Axiostat\u00ae dressing in achieving hemostasis in patients undergoing transradial coronary angioplasty (TRCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, single\u2010center observational study, conducted in 2022, enrolled consecutive patients undergoing TRCA, with a target of 150 participants. The primary outcome was the success rate of radial artery hemostasis at 120\u2009min, without bleeding necessitating immediate re\u2010compression. The secondary outcome included Axiostat\u00ae performance at 24\u2009h and 30 days Postprocedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study was terminated prematurely for ethical and patient safety reasons, after inclusion of 41 consecutive TRCA patients due to an unexpectedly high radial artery thrombosis rate (19.5%, <jats:italic>n<\/jats:italic>\u2009=\u20098\/41) observed 24\u2009h Postprocedure. The success rate of radial hemostasis with the Axiostat\u00ae dressing was 78.0%. Procedural details and patient characteristics were comparable between successful Axiostat\u00ae removal and device failure cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of the Axiostat\u00ae dressing to achieve hemostasis after TRCA is effective but is associated with an unexpectedly high incidence of radial thrombosis. Our results should encourage caution in the future evaluation and use of this device for radial artery compression following TRCA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31129","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:54:17Z","timestamp":1718585657000},"page":"234-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the safety and efficacy of the Axiostat\u00ae dressing device to achieve radial artery access hemostasis: The R3A study"],"prefix":"10.1002","volume":"104","author":[{"given":"Ariel","family":"Nakache","sequence":"first","affiliation":[{"name":"Cardiology Department Centre Cardiologique du Nord Saint Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Darmon","sequence":"additional","affiliation":[{"name":"Cardiology Department Centre Cardiologique du Nord Saint Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Molho","sequence":"additional","affiliation":[{"name":"Cardiology Department Centre Cardiologique du Nord Saint Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Steinecker","sequence":"additional","affiliation":[{"name":"Cardiology Department Centre Cardiologique du Nord Saint Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Nejjari","sequence":"additional","affiliation":[{"name":"Cardiology Department Centre Cardiologique du Nord Saint Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-8217","authenticated-orcid":false,"given":"Franck","family":"Digne","sequence":"additional","affiliation":[{"name":"Cardiology Department Centre Cardiologique du Nord Saint Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.06.045"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60292-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.08.023"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60404-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I11A192"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"issue":"3","key":"e_1_2_11_8_1","first-page":"101","article-title":"Impact of two different hemostatic devices on radial artery outcomes after transradial catheterization","volume":"21","author":"Pancholy SB","year":"2009","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.04.037"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002686"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22963"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2010.00584.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.12.030"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235889"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000199392.91772.44"},{"issue":"8","key":"e_1_2_11_16_1","article-title":"Pre\u2010hospital hemorrhagic control effectiveness of Axiostat\u00ae dressing versus conventional method in acute hemorrhage due to trauma","volume":"11","author":"Kabeer M","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2018.11.026"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBISRIR-2016-002964"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005430"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199702)40:2<156::AID-CCD7>3.0.CO;2-A"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27989"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27530"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29529"},{"issue":"2","key":"e_1_2_11_24_1","first-page":"E181","article-title":"Randomized trial comparing radial hemostasis techniques; 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