{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:13:45Z","timestamp":1748405625510,"version":"3.41.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronary microvascular dysfunction (CMD) after percutaneous coronary intervention (PCI) is prognostically important and may also be a cause of persistent angina. The stent balloon inflation technique or material properties may influence the degree of CMD post\u2010PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six patients with stable angina attending for elective PCI were randomized to either slow drug eluting stent (DES) implantation technique (DES slow group): +2\u2009atm. every 5\u2009s., maintained for a further 30\u2009s or a standard stent implantation technique (DES std group): rapid inflation and deflation. PressureWire X with thermodilution at rest and hyperemia and optical coherence tomography (OCT) were performed pre\u2010 and post\u2010PCI. Combined primary endpoints were changes in index of microvascular resistance (delta IMR) and coronary flow reserve (delta CFR) following PCI. The secondary endpoints included differences in cardiac troponin\u00a0I (delta cTnI) at 6\u2009h\u00a0post\u2010PCI, Seattle angina questionnaire (SAQ) at 1, 3, 6, and 12 months and OCT measures of stent results immediately post\u2010PCI and at 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups were well matched, with similar baseline characteristics and OCT\u2010defined plaque characteristics. Delta IMR was significantly better in the DES slow PCI arm with a median difference of \u22124.14 (95%\u00a0CI \u201010.49, \u22120.39, <jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.04<\/jats:italic>). Delta CFR was also numerically higher with a median difference of 0.47 (95% CI \u22120.52, 1.31, <jats:italic>p<\/jats:italic>\u2009=\u20090.46). This did not translate to improved delta median cTnI\u00a0(1.5 (34.8) vs. 0 (27.5) ng\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.75) or median SAQ score\u00a0at 3 months, (85 (20) vs. 95 (17.5), <jats:italic>p<\/jats:italic>\u2009=\u20090.47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Slow stent implantation is associated with less CMD after elective PCI in patients with stable angina.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31155","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T08:44:17Z","timestamp":1721810657000},"page":"462-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of microcirculatory protection in percutaneous revascularisation: A stent implantation technique and device comparison"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4010-5627","authenticated-orcid":false,"given":"Muhammad","family":"Aetesam\u2010ur\u2010Rahman","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitty","family":"Paques","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8723-670X","authenticated-orcid":false,"given":"Joana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Da","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Duckworth","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-2969","authenticated-orcid":false,"given":"Bharat","family":"Khialani","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Kyranis","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick E. 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