{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:10:30Z","timestamp":1753737030982,"version":"3.41.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012367","name":"MedStar Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 2019, the US Food and Drug Administration (FDA) approved transcatheter aortic valve replacement (TAVR) for low\u2010risk patients with symptomatic severe tricuspid aortic stenosis. However, bicuspid aortic valve (BAV) patients were included only in single\u2010arm registries of pivotal low\u2010risk TAVR trials, resulting in limited data for this subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The LRT (Low Risk TAVR) trial was an investigator\u2010initiated, prospective, multicenter study and the first\u00a0FDA\u2010approved investigational device exemption trial to evaluate the feasibility of TAVR with balloon\u2010expandable or self\u2010expanding valves in low\u2010risk patients with symptomatic severe BAV stenosis. This analysis reports 2\u2010year follow\u2010up, assessing the primary outcome of all\u2010cause mortality and evaluating clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2016 to 2019, a total of 72 low\u2010risk patients diagnosed with symptomatic, severe BAV stenosis underwent TAVR across six centers. Six patients were lost to follow\u2010up. At 2\u2010year follow\u2010up, mortality was 1.5% (1 of 66 patients). Among the remaining 65 patients, four experienced nondisabling strokes (6.2%), while 2 (3.1%) developed infective endocarditis. No new permanent pacemakers were required beyond the 30\u2010day follow\u2010up, and no patients, including those with endocarditis, needed aortic valve re\u2010intervention. At the 2\u2010year echocardiography follow\u2010up (<jats:italic>n<\/jats:italic>\u2009=\u200965), 27.8% of BAV patients showed mild aortic regurgitation, with none exhibiting moderate or severe regurgitation. The mean aortic gradient was 12.1\u2009\u00b1\u20094.1\u2009mmHg, and the mean valve area was 1.7\u2009\u00b1\u20090.5\u2009cm\u00b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 2\u2010year follow\u2010up confirms commendable clinical outcomes of TAVR in patients with bicuspid aortic stenosis, establishing its evident safety.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31170","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T09:24:20Z","timestamp":1723022660000},"page":"583-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010year follow\u2010up of transcatheter aortic valve replacement in low\u2010risk patients with symptomatic severe bicuspid aortic valve stenosis"],"prefix":"10.1002","volume":"104","author":[{"given":"Ilan","family":"Merdler","sequence":"first","affiliation":[{"name":"Section of Interventional Cardiology, MedStar 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Foundation for Cardiovascular Medicine Stanford University Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Roberts","sequence":"additional","affiliation":[{"name":"Sutter Medical Center, Sacramento, Sutter Heart and Vascular Institute, Research Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Hanna","sequence":"additional","affiliation":[{"name":"St. John Heart Institute Cardiovascular Consultants, St. John Health System Tulsa Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsik","family":"Ben\u2010Dor","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology, MedStar Washington Hospital Center Washington 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