{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:03:10Z","timestamp":1770897790545,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite optimal medical therapy and cardiac resynchronization therapy (CRT), significant functional mitral regurgitation (MR) persisted in 30% of the patients and labeled as CRT nonresponders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We sought to study the impact of transcatheter edge\u2010to\u2010edge repair (TEER) in patients with symptomatic grade III and IV functional MR despite CRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted of all patients who had prior CRT for at least 6 months and underwent TEER for significant residual functional MR (grade \u22653) and symptomatic heart failure (HF) at our institution. The primary outcomes were the change in New York Heart Association classification (NYHA), MR grade, echo parameters, and NT\u2010ProBNP from baseline to 1\u2010year post\u2010procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28 patients were identified, mean age of 73\u2009\u00b1\u20096.7 years and 89% males. Procedure success was achieved in all patients. At 1\u2010year follow\u2010up, patients had lower MR grade (median 2, IQR 1 [1,2] vs. 4, IQR 1 [3,4]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), NYHA class (median 2, IQR 1 [2,3] vs. 3, IQR 1 [3,4]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and NT\u2010ProBNP (7658\u2009\u00b1\u200911322 vs. 3760\u2009\u00b1\u20094431; <jats:italic>p<\/jats:italic>\u2009=\u20090.035) compared to before the TEER procedure. The left ventricular end\u2010diastolic volume (255\u2009\u00b1\u200959\u00a0vs. 244\u2009\u00b1\u200966\u2009mm; <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and the right ventricular systolic pressure (52\u2009\u00b1\u200914\u2009mmHg vs. 37\u2009\u00b1\u200913\u2009mmHg, &lt;0.001) decreased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients who remain symptomatic after CRT with severe functional MR had improved functional status and MR grade at 1\u2010year following TEER. There was a signal toward reverse remodeling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31190","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T20:09:47Z","timestamp":1723752587000},"page":"829-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of transcatheter edge to edge repair in functional mitral regurgitation and cardiac resynchronization\u2010therapy nonresponders"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-4049","authenticated-orcid":false,"given":"Bishoy","family":"Abraham","sequence":"first","affiliation":[{"name":"Division of Cardiovascular disease Mayo Clinic Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Suppah","sequence":"additional","affiliation":[{"name":"Department of Medicine Creighton University Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Megaly","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular disease Willis\u2010Knighton Medical Center Shreveport Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Elbanna","sequence":"additional","affiliation":[{"name":"Department of Medicine Rochester Regional Hospital Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Kaldas","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular disease Mayo Clinic Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Alsidawi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular disease Mayo Clinic Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"David 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