{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:20:26Z","timestamp":1781662826773,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paravalvular leakage (PVL) and conduction disorders that require permanent pacemaker implantation (PPI) remain clinically relevant challenges after transcatheter aortic valve implantation (TAVI). Computed tomography\u2010based simulations may predict the risk of significant PVL and PPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the feasibility and accuracy of preprocedural computer simulation with FEops HEARTguide\u2122 to predict &gt;trace PVL and PPI after TAVI with the self\u2010expanding supra\u2010annular ACURATE Neo2 transcatheter heart valve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective multicenter observational study that included consecutive patients undergoing TAVI with an ACURATE Neo2 valve. Computer simulations were performed before the TAVI procedure as part of the preprocedural planning. Follow\u2010up period for PPI and PVL was 30 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010five patients were included (median age 81 years (25th\u221275th percentile 77\u201384.5)). New left bundle branch block occurred in five patients (7.7%) and PPI in two patients (3%). Contact pressure index (CPI) was similar for patients with vs without new conduction disorders. Patients with PPI had numerically higher CPI than those without PPI (median CPI 20.0% (25th\u221275th percentile 15.0\u201325.0) vs. 13.0% (25th\u221275th percentile 5.5\u201318), <jats:italic>p<\/jats:italic>\u2009=\u20090.27). More than trace PVL occurred in 30%. Median PVL was significantly lower in patients with none\u2010trace PVL (3.2\u2009mL\/s [25th\u221275th percentile 2.2\u20135.0]), compared to mild PVL (5.2\u2009mL\/s [25th\u221275th percentile 3.2\u201310.3]) and moderate PVL (12.6\u2009mL\/s [25th\u221275th percentile 3.9\u201321.3])(<jats:italic>p<\/jats:italic>\u2009=\u20090.036). A simulated PVL\u2010cutoff of 9.65\u2009mL\/s identified patients with &gt;trace PVL (AUC 0.70 (95% CI 0.55\u20130.85), sensitivity 42%, specificity 95%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study FEops HEARTguide\u2122 simulations identified patients at risk for &gt;trace PVL with ACURATE Neo2 TAVI but not for PPI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31194","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T10:01:07Z","timestamp":1724839267000},"page":"1044-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CT\u2010derived simulations to predict outcomes in patients undergoing transcatheter aortic valve implantation with an ACURATE Neo2 valve the PRECISE\u2010TAVI cohort B trial"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-0011","authenticated-orcid":false,"given":"Thijmen W.","family":"Hokken","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute Thoraxcenter, Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-3367","authenticated-orcid":false,"given":"Philippe","family":"Nuyens","sequence":"additional","affiliation":[{"name":"The Heart Centre, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ruffo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger\u2010Jan","family":"Nuis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute Thoraxcenter, Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-1410","authenticated-orcid":false,"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute Thoraxcenter, Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Kardys","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute Thoraxcenter, Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute Thoraxcenter, Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-3739","authenticated-orcid":false,"given":"Nicola","family":"Buzzatti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-0278","authenticated-orcid":false,"given":"Ole","family":"de Backer","sequence":"additional","affiliation":[{"name":"The Heart Centre, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-1205","authenticated-orcid":false,"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute Thoraxcenter, Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezab389"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.12.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2019.11.015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32220-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.051547"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005344"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.003"},{"issue":"10","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009178","article-title":"Patient\u2010specific computer simulation of transcatheter aortic valve replacement in bicuspid aortic valve morphology","volume":"12","author":"Dowling C","year":"2019","journal-title":"Circulation Cardiovasc Imag"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11I9A212"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30816"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029464"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00164"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00498"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00289"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-00784"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:56:01Z","timestamp":1746420961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ccd.31194"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31194","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}