{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T12:08:08Z","timestamp":1759838888951,"version":"3.40.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve implantation (TAVI) is a well\u2010established intervention for severe aortic valve stenosis. However, its application for severe aortic regurgitation (AR) is still under evaluation. This study aims to present the 3\u2010year follow\u2010up outcomes of the J\u2010Valve system in managing severe AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to evaluate the mid\u2010term efficacy and durability of the J\u2010Valve system in the treatment of severe AR and to provide new information on this intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective, single\u2010center study, we evaluated the prognostic outcomes of patients with AR, who underwent treatment with the J\u2010Valve system at Nanjing Drum Tower Hospital. Consecutive patients who were treated with the J\u2010Valve were included in the analysis. The study focused on the echocardiographic follow\u2010up to assess the effectiveness and durability of the J\u2010Valve system in managing AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2018 to December 2022, 36 high\u2010risk AR patients treated with the J\u2010Valve system had a procedural success rate of 97.2%, with one case requiring open\u2010heart surgery due to valve displacement. Significant improvements were observed in left ventricular diameter (from 63.50 [58.75\u201369.50]\u2009mm to 56.50 [53.00\u201360.50]\u2009mm, <jats:italic>p<\/jats:italic> &lt;\u20090.001) and left atrial diameter (from 44.00 [40.00\u201345.25]\u2009mm to 39.00 [36.75\u201341.00]\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) postsurgery. All patients completed the 1\u2010year follow\u2010up, with an overall mortality rate of 2 out of 36 (5.6%). Among the surviving patients, there was one case of III\u00b0 atrioventricular block and one case of stroke, both occurring within 90 days postsurgery. After a 3\u2010year follow\u2010up, 15.0% of patients had mild or moderate valvular regurgitation, with no cases of moderate or severe paravalvular leak. Additionally, 89.5% of patients were classified as New York Heart Association class I or II, showing significantly enhanced cardiac function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The J\u2010Valve system has shown positive therapeutic outcomes in treating AR, with notable effectiveness in managing the condition and significant improvements in heart failure symptoms and cardiac remodeling. However, due to the limited sample size and partial follow\u2010up data, it is important to emphasize the need for further research with comprehensive long\u2010term follow\u2010up, to fully validate these results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31196","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T10:18:23Z","timestamp":1725877103000},"page":"1052-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcatheter aortic valve implantation for severe aortic regurgitation using the J\u2010Valve system: A midterm follow\u2010up study"],"prefix":"10.1002","volume":"104","author":[{"given":"Min","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Nanjing Drum Tower Hospital, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical College Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuchun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-1972","authenticated-orcid":false,"given":"Dongjin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing China"},{"name":"Department of Cardiac Surgery Nanjing Drum Tower Hospital, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical College Nanjing China"},{"name":"Department of Cardiac Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.044"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307447"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.04.048"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.02.017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.11.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.09.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.07.038"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-015-0207-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.03.054"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.09.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.10.021"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.06.139"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.07.037"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27253"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.06.050"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00344"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:56:00Z","timestamp":1746420960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ccd.31196"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31196","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2024,9,9]]},"assertion":[{"value":"2024-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}