{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:34:19Z","timestamp":1782930859554,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve implantation (TAVI) leads to transient platelet activation and hypercoagulation status, resulting in thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study investigated the associations of coagulation\/fibrinolysis status after transfemoral TAVI with valve type, post\u2010TAVI thrombocytopenia, and complication of TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thrombin\u2013antithrombin complex (TAT) and fibrin\/fibrinogen degradation product (FDP) levels were measured before and 1\u2009h, 1 day, and 2 days after TAVI. A percentage drop in platelet count (DPC) was determined from the pre\u2010 and lowest post\u2010procedural values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SAPIEN 3 (S3) was implanted in 158 patients and Evolut PRO\/PRO+ (Evolut) in 117. Both TAT and FDP increased after TAVI. Pre\u2010TAVI balloon dilatation was generally performed on patients undergoing implantation with Evolut. Peak TAT was then stratified into 4 quartiles (Q1 to Q4). Of all 275 study patients, 69 patients reached ultra\u2010hypercoagulation status (Q4). S3, TAVI without pre\u2010balloon dilatation, DPC and bleeding complications were significantly associated with the ultra\u2010hypercoagulation status after TAVI. TAT was significantly greater 1\u2009h after S3 implantation than Evolut (median [IQR], 43.1 [34.1\u201359.6] vs. 31.0 [25.0\u201340.4] ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In contrast, FDP levels did not differ between the two at any measurement point. The difference in DPC among the peak TAT quartiles was statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The occurrence of bleeding complications was significantly higher in the group with ultra\u2010hypercoagulation status (5.8% vs. 1.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The increase in coagulation status and post\u2010TAVI thrombocytopenia were significantly greater after S3 implantation. Ultra\u2010hypercoagulation after TAVI was related to bleeding complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31199","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:34:29Z","timestamp":1724294069000},"page":"1281-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Coagulation, fibrinolysis and platelet drop in patients undergoing transfemoral transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"104","author":[{"given":"Taiga","family":"Katayama","sequence":"first","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8395-228X","authenticated-orcid":false,"given":"Naoyuki","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-5303","authenticated-orcid":false,"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-1248","authenticated-orcid":false,"given":"Hideyuki","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Hioki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-5973","authenticated-orcid":false,"given":"Ken","family":"Kozuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Teikyo University School of Medicine Tokyo 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