{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:04:51Z","timestamp":1781309091120,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Hemodynamic impact of commissural alignment (CA) with self\u2010expandable transcatheter aortic valves (TAVR) has not been investigated yet.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To determine hemodynamic impact of CA with self\u2010expandable TAVR.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Multicentric ambispective study comparing patients who underwent self\u2010expandable TAVR in seven centers with the Evolut Pro\/Pro+ (EP) (Medtronic) and Acurate neo2 (AN2) (Boston Scientific) with and without CA strategies. The degree of commissural misalignment (CMA) was assessed by computed tomography\/angiography and 1\u2010year transvalvular gradients\/regurgitation evaluated by echocardiography. A matched comparison according to annular dimensions\/eccentricity, prosthesis size\/type, and baseline left ventricular function and gradients was performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 557 patients, mean age 80.7\u2009\u00b1\u20096.6 years, 61.4% men, and STS score of 4.3\u2009\u00b1\u20093.1% were analyzed. A CA technique was attempted in 215 patients (38.6%), including 113 patients with AN2 and 102 patients with EP. None\/mild CMA was found in 158 (73.5% vs. 43.6% if no CA attempted,\n p<\/jats:italic>\n \u2009<\u20090.001) with no differences between devices (AN2:75.2%; EP:71.6%,\n p<\/jats:italic>\n \u2009=\u20090.545). Patients with moderate\/severe CMA had a greater aortic peak gradient (22.3\u2009\u00b1\u20098.7 vs. 19.7\u2009\u00b1\u20098.5,\n p<\/jats:italic>\n \u2009=\u20090.001), significantly greater progression of both peak (\n p<\/jats:italic>\n \u2009=\u20090.002) and mean gradients (\n p<\/jats:italic>\n \u2009=\u20090.001) after matching, and higher rate of central aortic regurgitation (1.2% vs. 0.4%,\n p<\/jats:italic>\n \u2009=\u20090.005) at 1\u2010year, but not a greater proportion of patients with mean gradient\u2009\u2265\u200910\u2009mmHg.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The use of CA strategies significantly reduced the rate of CMA for the self\u2010expandable TAVR devices ACN2 and EP which was associated to lower transvalvular gradients and intra\u2010prosthetic regurgitation progression at 1\u2010year although no criteria of structural deterioration were met at this follow up.\n Clinicaltrials.org<\/jats:ext-link>\n : NCT05097183.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ccd.31201","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T03:51:23Z","timestamp":1725940283000},"page":"1060-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of commissural alignment on the hemodynamic performance of supra\u2010annular self\u2010expandable transcatheter aortic valves"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-4129","authenticated-orcid":false,"given":"Ignacio J.","family":"Amat\u2010Santos","sequence":"first","affiliation":[{"name":"Cardiology Department University Clinic Hospital Valladolid Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red \u2010 Enfermedades cardiovasculares (CIBERCV) Instituto de salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"G\u00f3mez\u2010Herrero","sequence":"additional","affiliation":[{"name":"Cardiology Department University Clinic Hospital Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Pinon","sequence":"additional","affiliation":[{"name":"Cardiology Department Complejo Hospitalario de La Coru\u00f1a A Coruna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-8907","authenticated-orcid":false,"given":"Luis","family":"Nombela\u2010Franco","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-1174","authenticated-orcid":false,"given":"Ra\u00fal","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Munoz\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Virgen de La Victoria M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Redondo","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario de Santiago Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"G\u00f3mez\u2010Menchero","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Juan Ram\u00f3n Jimenez Huelva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"G\u00f3mez\u2010Salvador","sequence":"additional","affiliation":[{"name":"Cardiology Department University Clinic Hospital Valladolid Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red \u2010 Enfermedades cardiovasculares (CIBERCV) Instituto de salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alberto","family":"San Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Cardiology Department University Clinic Hospital Valladolid Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red \u2010 Enfermedades cardiovasculares (CIBERCV) Instituto de salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.04.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2017.10.032"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.11.063"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3316"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.07.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2021.08.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.06.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2021.02.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2016.12.031"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.05.043"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.02.021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1240"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2023.01.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-023-02192-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivy039"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.04.020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.10.005"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:55:58Z","timestamp":1746406558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ccd.31201"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31201","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.23.23290422","asserted-by":"object"}]},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,10]]},"assertion":[{"value":"2024-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}