{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:16:41Z","timestamp":1792192601151,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bleeding and stroke are frequent complications after transcatheter aortic valve implantation (TAVI). The mortality risk associated with these events has been reported before, but data regarding their impact on health\u2010related quality of life (QoL) is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the impact of bleeding and stroke occurring within 30 days after TAVI, on mortality and QoL during the first year after TAVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>POPular TAVI was a randomized clinical trial that evaluated the addition of clopidogrel to aspirin or oral anticoagulation in patients undergoing TAVI. Besides clinical outcomes, QoL was assessed using the Short Form\u201012 and EuroQoL Five Dimensions questionnaires before, and at 3, 6, and 12 months after TAVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Major or life\u2010threatening bleeding occurred in 81 patients (8.3%) and was associated with an increased risk of death (hazard ratio [HR] 1.95 [95% confidence interval (CI) 1.00\u20133.79]); minor bleeding occurred in 104 patients (10.6%) and was not associated with mortality (HR 0.75 [95% CI 0.30\u20131.89]). Stroke occurred in 35 patients (3.6%) and was associated with an increased risk of death (HR 2.90 [95% CI 1.23\u20136.83]). Mean mental component summary (MCS\u201012) scores over time were lower in patients with major or life\u2010threatening bleeding (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), and similar in patients with minor bleeding, compared to patients without bleeding; mean physical component summary (PCS\u201012) scores, EQ\u20105D index, and visual analog scale (VAS) were similar between those patients. Mean MCS\u201012 scores were lower in patients with stroke (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), mean PCS\u201012, EQ\u20105D index, and VAS were similar compared to patients without stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Major or life\u2010threatening bleeding and stroke were associated with an increased risk of death and decreased mental QoL in the first year after TAVI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31218","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T07:19:06Z","timestamp":1726039146000},"page":"1107-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of stroke and bleeding on mortality and quality of life during the first year after TAVI: A POPular TAVI subanalysis"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-8448","authenticated-orcid":false,"given":"Puck J. 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