{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:20:23Z","timestamp":1792491623477,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While it is broadly accepted that ageing is associated with impairment of coronary microvascular function, little is known about the underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated age\u2010related changes in coronary microvascular structure in patients with stable angina without epicardial coronary stenoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an analysis of the IDEAL registry, a total of 165 vessels without coronary stenosis were interrogated with combined pressure\/Doppler guidewires. We calculated diastolic microvascular conductance (DMVC) and backward expansion wave (BEW), and compared them between age tertiles. We calculated the prevalence of CMD, defined by reduced coronary flow reserve (CFR), and the prevalence of low BEW and low DMVC in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three study groups were defined as having 37\u201353, 54\u201366, and 67\u201377 years of age, respectively. Oldest (3rd tertile) patients showed lower hyperemic flow velocity (46.7\u2009\u00b1\u200914.4 vs. 45.1\u2009\u00b1\u200912.4 vs. 38.4\u2009\u00b1\u200911.5\u2009cm\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.019), lower DMVC (1.90\u2009\u00b1\u20090.71 vs. 1.44\u2009\u00b1\u20090.56 vs. 1.37\u2009\u00b1\u20090.67\u2009cm\u2009s<jats:sup>\u22121<\/jats:sup>\u2009mmHg<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and lower BEW intensity (5.9 [2.9\u20138.4] vs. 4.8 [2.9\u20136.8] vs. 4.4 [3.4\u20136.3]\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> W\u2009m<jats:sup>\u22122<\/jats:sup>\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.094). Older age was independently associated with lower BEW intensity (<jats:italic>B<\/jats:italic>: \u22120.10, 95% confidence interval [CI]: \u22120.17 to \u22120.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.021) and DMVC (<jats:italic>B<\/jats:italic>: \u22120.25 95% CI: \u22120.45 to \u22120.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.027). In patients with CFR\u2009&lt;\u20092.5, the prevalence of BEW intensity and DMVC below the 25th percentile increased with age (25.0% vs. 52.0% vs. 72.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ageing is independently associated with structural microcirculatory remodeling that is reflected in BEW intensity and DMVC measurements, and with an increased prevalence of structural CMD. These results are important to understand non\u2010obstructive mechanisms of myocardial ischemia in the elderly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31223","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T05:10:27Z","timestamp":1726463427000},"page":"968-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Age\u2010related structural remodelling of the coronary circulation"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-6786","authenticated-orcid":false,"given":"Daniel","family":"Faria","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBERCV Madrid Spain"},{"name":"Centro Hospitalar Universit\u00e1rio do Algarve, Hospital de Faro Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-2859","authenticated-orcid":false,"given":"Marco","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBERCV Madrid Spain"},{"name":"Department of Internal Medicine University of Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology Amsterdam UMC, University of Amsterdam Heart Center, Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-2592","authenticated-orcid":false,"given":"Alejandro","family":"Travieso","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBERCV Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-5227","authenticated-orcid":false,"given":"Julius C.","family":"Heemelaar","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology Amsterdam UMC, University of Amsterdam Heart Center, Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhjinder S.","family":"Nijjer","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-1926","authenticated-orcid":false,"given":"Hern\u00e1n","family":"Mej\u00eda\u2010Renter\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBERCV Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guus A.","family":"de Waard","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology Amsterdam UMC, University of Amsterdam Heart Center, Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Sen","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim P.","family":"van de Hoef","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Petraco","sequence":"additional","affiliation":[{"name":"International Centre of Circulatory Health, National Heart and Lung Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Echavarr\u00eda\u2010Pinto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital General ISSSTE Queretaro, Quer\u00e9taro, Mexico and Autonomous University of Queretaro Queretaro M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"Piek","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology Amsterdam UMC, University of Amsterdam Heart Center, Amsterdam Cardiovascular Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"van Royen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC, Complutense University of Madrid and CIBERCV Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-20-01163"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30092"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041595"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-017-1136-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009625"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043916"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccl.2015.06.005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.4.941"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00021"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx732"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.834739"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.21542\/gcsp.2017.5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.603050"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv626"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003995"},{"key":"e_1_2_11_16_2","doi-asserted-by":"crossref","unstructured":"Erratum in: J Am Heart Assoc.2017Jan 11;6(1):e002163.doi:10.1161\/JAHA.116.002163","DOI":"10.1161\/JAHA.116.002163"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M03_09"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000099521.31396.9D"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004482"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.003779"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-009-0439-y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab246"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa503"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002356"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90869-B"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.229914"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30445"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2003.11.016"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000659"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0074-7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.05.114"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht513"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00778"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.43.2.242"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.765071"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(09)73125-2"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:55:57Z","timestamp":1746420957000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,15]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ccd.31223"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31223","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,15]]},"assertion":[{"value":"2024-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}