{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:26:21Z","timestamp":1773030381046,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We previously showed non\u2010inferiority of a low\u2010dose paclitaxel\u2010coated balloon (PCB) with citrate excipient (Agent PCB) as compared to normal\u2010dose iopromide excipient (SeQuent Please PCB) in terms of angiographic and clinical endpoints at 12 months. The long\u2010term clinical efficacy and safety of Agent PCB is not defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>262 patients (323 DES\u2010ISR lesions) were enrolled in this study and treated with either Agent PCB (125 patients, 151 lesions) in the ISAR\u2010DESIRE 3a trial or with SeQuent Please PCB (137 patients, 172 lesions) in the setting of the randomized ISAR\u2010DESIRE 3 trial with similar in\u2010 and exclusion criteria serving as historical control arm. The follow\u2010up period was extended to 7 years. The efficacy and safety endpoints of this analysis were target\u2010lesion revascularization (TLR), death, myocardial infarction (MI) and target lesion thrombosis (TLT) at 7 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 7 years, 206 patients (78.6%) were alive. The risks of TLR (hazard ratio [HR]: 1.29, 95% confidence interval [CI]: 0.87\u20131.90; <jats:italic>p<\/jats:italic>\u2009=\u20090.205), death (HR: 1.38, 95% CI: 0.82\u20102.35; <jats:italic>p<\/jats:italic>\u2009=\u20090.227), MI (HR: 1.10, 95% CI: 0.39\u20133.15; <jats:italic>p<\/jats:italic>\u2009=\u20090.852) and TLT (HR: 2.18, 95% CI: 0.20\u201324.10; <jats:italic>p<\/jats:italic>\u2009=\u20090.523) were comparable between Agent PCB and SeQuent PCB. Multivariate analysis showed comparable risks of TLR, death and MI between both PCB devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients treated for DES\u2010ISR by angioplasty with Agent PCB and SeQuent Please PCB, there was no statistically significant difference in TLR at 7 years. Randomized trials with standardized lesion preparation and long\u2010term follow\u2010up are warranted to further evaluate comparative efficacy of both devices. (ClinicalTrials. gov Identifier: NCT02367495).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31228","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T07:40:17Z","timestamp":1726645217000},"page":"909-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative long\u2010term efficacy and safety of two paclitaxel\u2010coated balloons with different coating strategies for the treatment of drug\u2010eluting coronary stent restenosis"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-9103","authenticated-orcid":false,"given":"Tobias","family":"Koch","sequence":"first","affiliation":[{"name":"ISAResearch Zentrum, Kardiologie, Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t M\u00fcnchen Munich 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