{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:11:51Z","timestamp":1792159911644,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal treatment strategy for coronary calcified nodules (CN) remains uncertain. We aimed to evaluate the efficacy and safety of different calcium modification strategies, including rotational atherectomy (RA), orbital atherectomy (OA), and intravascular lithotripsy (IVL) for managing CN with optical coherence tomography (OCT) guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients undergoing OCT\u2010guided percutaneous coronary intervention (PCI) for severely calcified lesions using RA, OA, or IVL between January 2017 and December 2022 were included. Primary endpoint was minimum stent area (MSA) post\u2010PCI. Secondary endpoints included MSA at CN site and 1\u2010year target vessel failure (TVF), defined as a composite of cardiac death, target\u2010vessel myocardial infarction, or target vessel revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 154 patients and 158 lesions, CN was identified in 54 lesions (34.2%) and managed with RA (39%, <jats:italic>n<\/jats:italic>\u2009=\u200921), OA (33%, <jats:italic>n<\/jats:italic>\u2009=\u200918), or IVL (28%, <jats:italic>n<\/jats:italic>\u2009=\u200915). The IVL group exhibited a larger minimal lumen diameter, maximum calcium arc, and maximum calcium thickness. Post\u2010PCI OCT demonstrated comparable MSA (RA: 6.23\u2009\u00b1\u20090.34\u2009mm\u00b2, OA: 5.75\u2009\u00b1\u20090.39\u2009mm\u00b2, IVL: 6.24\u2009\u00b1\u20090.46\u2009mm\u00b2; <jats:italic>p<\/jats:italic>\u2009=\u20090.62) and MSA at CN site (7.17\u2009\u00b1\u20090.43\u2009mm\u00b2, 6.46\u2009\u00b1\u20090.49\u2009mm\u00b2, 7.86\u2009\u00b1\u20090.56\u2009mm\u00b2, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.55) after adjusting for morphologic factors. The incidence of TVF at 1 year was similar among the group (RA: 19.0%, OA: 22.2%, IVL: 13.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing PCI for CN, similar procedural and clinical outcomes can be achieved using RA, OA, or IVL. These findings warrant further investigation in larger, prospective trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31246","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T11:00:18Z","timestamp":1729681218000},"page":"1373-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rotational, orbital atherectomy and intravascular lithotripsy for coronary calcified nodules: insights from optical coherence tomography"],"prefix":"10.1002","volume":"104","author":[{"given":"Keisuke","family":"Yasumura","sequence":"first","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop N.","family":"Koshy","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Cardiology Austin Health &amp; the University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Vinayak","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Vengrenyuk","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Minatoguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parasuram","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Hooda","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sweeny","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samin K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-3307","authenticated-orcid":false,"given":"Annapoorna S.","family":"Kini","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Zena and Michael A. 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