{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:26:23Z","timestamp":1751689583673,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary angioplasty is the standard procedure for patients with ST\u2010segment elevation myocardial infarction (STEMI). However, myocardial reperfusion results in additional cell damage. Levosimendan, due to its pleiotropic effects, may be a therapeutic alternative to prevent this damage. The objective of this study was to evaluate whether this drug can reduce infarct size in patients with STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomized to receive a 24\u2010h infusion of either levosimendan (0.1\u2009\u03bcg\/kg\/min) or placebo after the primary angioplasty. The main objective was to assess the size of the infarct by cardiac resonance at 30 days and 6 months after the event. Other variables such as left ventricular ejection fraction (LVEF) and adverse ventricular remodeling (AVR) were assessed by speckle\u2010tracking echocardiography and magnetic resonance. Major adverse cardiovascular events (MACE) were also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>157 patients were analysed (levosimendan, <jats:italic>n<\/jats:italic>\u2009=\u200979; placebo, <jats:italic>n<\/jats:italic>\u2009=\u200978). We found that after 6 months, patients treated with levosimendan had a greater reduction in infarct size (13.19%\u2009\u00b1\u20099.5% vs.11.79%\u2009\u00b1\u20099%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), compared with those in the placebo group (13.35% \u00b1 7.1% vs. 13.43% \u00b1 7.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.38). There were no significant differences in MACE between both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Levosimendan is a safe and effective therapeutic option for reducing infarct size in patients with STEMI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31267","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T08:49:10Z","timestamp":1729327750000},"page":"1414-1422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of levosimendan in patients with ST\u2010segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: The LEVOCEST trial"],"prefix":"10.1002","volume":"104","author":[{"given":"Francisco","family":"Bosa Ojeda","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology University Hospital of the Canary Islands La Laguna, Santa Cruz de Tenerife Canary 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M.","family":"Izquierdo G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of the Canary Islands La Laguna, Santa Cruz de Tenerife Canary Islands Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Jim\u00e9nez Sosa","sequence":"additional","affiliation":[{"name":"Research Unit University Hospital of the Canary Islands La Laguna, Santa Cruz de Tenerife Canary Islands Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Rodr\u00edguez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Service Clinical Research and Clinical Trials Unit of the University Hospital of the Canary Islands Canary Islands Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"S\u00e1nchez\u2010Grande Flecha","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology University 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