{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:34:17Z","timestamp":1793644457932,"version":"4.5.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemophilia is a disease characterized by a high risk of bleeding. With advances in treatment, life expectancy and aging\u2010associated diseases such as coronary artery disease have increased. Our primary objective is to assess for major adverse outcomes, mortality, and length of hospital stay in individuals with hemophilia presenting for acute coronary syndrome (ACS) and undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our retrospective cohort study analyzed data from the Nationwide Inpatient Sample Database (NIS) for 2018 to investigate the outcomes of ACS management with PCI in adults with and without hemophilia. We used ICD\u201010 codes to exclude patients with significant comorbidities and identify those with ACS undergoing PCI. Propensity score matching and multivariable logistic regression were employed to account for over 20 baseline characteristics, mitigating confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of gastrointestinal bleeding (11.0% vs. 2.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), hemorrhagic stroke (10.0% vs. 1.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and retroperitoneal hemorrhage (5.6% vs. 1.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was significantly higher in individuals with hemophilia undergoing PCI compared to those without hemophilia. Additionally, venous thromboembolism (VTE) incidence was notably higher in the hemophilia cohort (6.6% vs. 2.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.027). The hemophilia cohort also experienced a higher mortality rate (7.1% vs. 3.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.037) and longer hospital stays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with hemophilia undergoing PCI are at a significantly greater risk of adverse events, increased mortality, and longer hospital stays than the general population. To mitigate the risk of unfavorable outcomes, it is crucial to ensure adequate replenishment of coagulation factors and establish close collaboration between cardiologists and hematologists.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31269","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:10:06Z","timestamp":1729231806000},"page":"1387-1395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clots and bleeds: the outcomes of percutaneous coronary intervention in hemophilia patients with acute coronary syndrome"],"prefix":"10.1002","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3015-0715","authenticated-orcid":false,"given":"Michel Al","family":"Achkar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1693-6746","authenticated-orcid":false,"given":"Georges","family":"Khattar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Asmar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"El Khoury","sequence":"additional","affiliation":[{"name":"Department of Cardiology Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares","family":"Saliba","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Aoun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Al","family":"Saidi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Araji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie Bou","family":"Sanayeh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Vascular Medicine Staten Island University Hospital\/Northwell Health Staten Island New York USA"},{"name":"Chair of Cardiology Staten Island University Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bershadskiy","sequence":"additional","affiliation":[{"name":"Departement of Hematology and Medical Oncology Staten Island Univesity Hospital\/Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"121","article-title":"Haemophilia B is clinically less severe than haemophilia A: further evidence","volume":"16","author":"Franchini M","year":"2018","journal-title":"Blood Transfusion"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106073442307"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050435"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.10.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-07-0460"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20339"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02020.x"},{"key":"e_1_2_9_9_1","unstructured":"M. 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