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Catheter\u2010directed thrombolysis has emerged as a promising option for patients with intermediate\u2010risk pulmonary embolism which aims to improve outcomes over standard anticoagulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We constructed a decision\u2010analytic model comparing the cost\u2010effectiveness of catheter\u2010directed thrombolysis to anticoagulation alone for the management of intermediate\u2010risk pulmonary embolism. Cost\u2010effectiveness was determined by calculating deaths averted and incremental cost\u2010effectiveness ratios (ICER). Uncertainty was addressed by plotting cost\u2010effectiveness planes and acceptability curves for various willingness\u2010to\u2010pay thresholds. The main outcome was ICER (US dollars\/deaths averted).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the base case analysis, derived using systemic lysis data, the cost associated with catheter\u2010directed thrombolysis was estimated at $22,353 with a probability of survival at 1 month of 0.984. For the anticoagulation alone strategy, the cost was $25,060, and the probability of survival at 1 month was 0.958. Overall, catheter\u2010directed thrombolysis resulted in savings of $104,089 per death averted (ICER,\u2014$104,089 per death averted). Sensitivity analysis revealed that catheter\u2010directed thrombolysis would no longer be cost\u2010effective when its associated mortality is greater than 0.042. In the probabilistic analysis, at a willingness\u2010to\u2010pay of $100,000, catheter\u2010directed thrombolysis had a 63% chance of being cost\u2010effective, and in cost\u2010effectiveness acceptability curves, it was cost\u2010effective in 63%\u201378% of simulations for a willingness to pay ranging from $0 to $100,000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>If the assumptions made in our model are shown to be accurate then CDT would be cost\u2010effective and may lead to considerable cost savings if used where clinically appropriate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31280","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T05:50:05Z","timestamp":1731736205000},"page":"326-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Economic Analysis of Catheter\u2010Directed Thrombolysis for Intermediate\u2010Risk Pulmonary 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