{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:55:45Z","timestamp":1782867345315,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Trials comparing non\u2010vitamin K oral anticoagulant (NOAC) versus antiplatelet\u2010based strategies have shown a reduction of subclinical leaflet thrombosis at the cost of increased mortality and major\u2010bleedings. NOACs were often combined with antiplatelet therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The Rotterdam Edoxaban (REDOX) study aimed to evaluate the impact of edoxaban monotherapy on the incidence of hypo\u2010attenuated leaflet thickening (HALT) and reduced leaflet motion (RLM) and to evaluate safety in terms of mortality, thromboembolic events and major bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The REDOX study is a single\u2010arm, open\u2010label trial including patients after successful transcatheter aortic valve implantation (TAVI) with no formal indication for oral anticoagulation or dual antiplatelet therapy. Patients received edoxaban monotherapy for 3 months, followed by multislice computed tomography (MSCT). The primary endpoint was the occurrence of HALT. Clinical follow\u2010up continued up to 1 year after TAVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 58 patients, of which 50 reached study completion including MSCT scanning and eight withdrew consent before end of study. At 3\u2010months follow\u2010up, HALT of any grade was detected in 12.0% (95% confidence interval (CI): 5.0%\u201323.1%) of patients. HALT grade\u2009\u2265\u20093 occurred in 4.0% (95% CI: 0.8%\u201312.2%) of patients. At 1 year follow\u2010up, all patients were alive and free of disabling strokes. Three patients had a non\u2010disabling stroke and one patient had a major bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the REDOX study, edoxaban monotherapy after TAVI was associated with a 12.0% incidence of any HALT and a 4.0% incidence of HALT grade\u2009\u2265\u20093. HALT was not associated with clinical events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31300","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T12:54:39Z","timestamp":1732280079000},"page":"375-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Edoxaban Monotherapy and Incidence of Transcatheter Heart Valve Leaflet Thrombosis \u2014 The Rotterdam Edoxaban (REDOX) Study"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1001-8840","authenticated-orcid":false,"given":"Rik","family":"Adrichem","sequence":"first","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-8605","authenticated-orcid":false,"given":"Maarten P.","family":"van Wiechen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-1907","authenticated-orcid":false,"given":"Wiebe G.","family":"Knol","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-0011","authenticated-orcid":false,"given":"Thijmen W.","family":"Hokken","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-7609","authenticated-orcid":false,"given":"Joris F.","family":"Ooms","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2124-109X","authenticated-orcid":false,"given":"Mark M. P.","family":"van den Dorpel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9822-7833","authenticated-orcid":false,"given":"Sarah","family":"Verhemel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-9745","authenticated-orcid":false,"given":"Isabella","family":"Kardys","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-6707","authenticated-orcid":false,"given":"Rutger\u2010Jan","family":"Nuis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-1410","authenticated-orcid":false,"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-2006","authenticated-orcid":false,"given":"Alexander","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-615X","authenticated-orcid":false,"given":"Ricardo P. 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