{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:00:05Z","timestamp":1772982005621,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite growing evidence of its clinical implications, assessment of coronary microvascular dysfunction (CMD) remains limited in routine clinical practice. Hence, there is an increasing interest in angiography\u2010derived indices to encourage assessment of CMD in the cardiac catheterisation laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      We investigate here an alternative approach, using a combination of pressure\u2010wire\u2010based assessment of distal coronary pressure (P\n                      <jats:sub>d<\/jats:sub>\n                      ) and an angiography\u2010derived surrogate of coronary flow, to derive a hybrid index of microcirculatory resistance (IMR\n                      <jats:sub>hybrid<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients enroled prospectively under the Oxford Acute Myocardial Infarction (OxAMI) study were included in the OxAMI HYBRID substudy. The accuracy of IMR\n                      <jats:sub>hybrid<\/jats:sub>\n                      was assessed in diagnosing CMD using bolus thermodilution\u2010based Index of Microcirculatory Resistance (IMR) as a reference. The accuracy of IMR\n                      <jats:sub>hybrid<\/jats:sub>\n                      was then compared against a fully angiography\u2010derived index of microvascular resistance (IMR\n                      <jats:sub>angio<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and eighty six patients were enroled, of which 121 with acute coronary syndrome and 65 with stable coronary artery disease. A total of 240 vessel analyses were performed. Both IMR\n                      <jats:sub>hybrid<\/jats:sub>\n                      and IMR\n                      <jats:sub>angio<\/jats:sub>\n                      correlated with IMR (rho\u2009=\u20090.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and rho\u2009=\u20090.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 respectively) and showed good and comparable overall diagnostic accuracy in predicting IMR\u2009\u2265\u200925 (80.8% and 83.1% respectively) with a receiver operator curve (ROC) analyses showing similar AUC of 0.86 (95% CI 0.82\u20130.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for IMR\n                      <jats:sub>hybrid<\/jats:sub>\n                      and 0.86 (95% CI 0.809\u20130.906,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for IMR\n                      <jats:sub>angio<\/jats:sub>\n                      , p for comparison\u2009=\u20090.641.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Both approaches, IMR\n                      <jats:sub>hybrid<\/jats:sub>\n                      and IMR\n                      <jats:sub>angio<\/jats:sub>\n                      are viable and comparable indices correlating with bolus thermodilution\u2010based IMR and retaining good diagnostic accuracy. IMR\n                      <jats:sub>hybrid<\/jats:sub>\n                      specifically is a simple alternative to conventional bolus thermodilution\u2010based IMR applicable to any pressure wire system.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31311","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:35:34Z","timestamp":1732494934000},"page":"81-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of a Fully Angiography\u2010Derived Versus a Hybrid of Angiography and Pressure\u2010Wire\u2010Derived Approach to Assess Coronary Microvascular Resistance: The Oxford Acute Myocardial Infarction Hybrid (OxAMI\u2010HYBRID) Study"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-9564","authenticated-orcid":false,"given":"Jason","family":"Chai","sequence":"first","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Marin","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Scarsini","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafail","family":"Kotronias","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Benenati","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"},{"name":"Department of Internal Medicine (Di.M.I.) University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Chu","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"},{"name":"School of Biomedical Engineering, Biomedical Instrument Institute Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam S.","family":"Couch","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Langrish","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"OxAMI Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Channon","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"},{"name":"National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Banning","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"},{"name":"National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Luigi","family":"De Maria","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Trust Oxford UK"},{"name":"National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.01.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-021-02254-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-01831-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.605356"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009603"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037350"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S413991"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.02.018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.123.013556"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005409"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00043"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00772"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00378"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M07_02"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.051"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-024-03202-y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.07.011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.09.012"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.31311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:36:01Z","timestamp":1772958961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,24]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ccd.31311"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31311","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,24]]},"assertion":[{"value":"2024-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}