{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:59:50Z","timestamp":1772981990847,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The consensus on whether acute ST\u2010segment elevation myocardial infarction (STEMI) patients with multivessel coronary artery disease (MVD) benefit from complete revascularization during primary percutaneous coronary intervention (PCI) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to assess the impact of multivessel PCI (MV\u2010PCI) versus culprit\u2010vessel\u2010only PCI (CV\u2010PCI) on in\u2010hospital outcomes in a Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated STEMI patients with MVD undergoing PCI, registered in the Improving Care for Cardiovascular Disease in China\u2010Acute Coronary Syndrome (CCC\u2010ACS) project, from November 2014 to December 2019. Using inverse probability of treatment weighting (IPTW) and multivariable Cox regression, we compared the incidence of in\u2010hospital Major Adverse Cardiac Events (MACE) and other adverse clinical outcomes between the MV\u2010PCI and CV\u2010PCI groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 8138 patients included, 840 (10.3%) underwent MV\u2010PCI, and 7298 (89.7%) underwent CV\u2010PCI. MV\u2010PCI was associated with higher in\u2010hospital MACE (2.0% vs. 0.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), all\u2010cause mortality (1.7% vs. 0.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and contrast\u2010induced acute kidney injury (CI\u2010AKI) (13.6% vs. 10.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), after IPTW adjustment. The multivariable Cox analysis further validated the increased risks associated with MV\u2010PCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the Chinese STEMI population with MVD, participating in the CCC\u2010ACS project, MV\u2010PCI during primary PCI was linked to higher in\u2010hospital adverse events compared to CV\u2010PCI. These findings advocate for a cautious approach to MV\u2010PCI in this setting, suggesting a potential preference for a staged PCI strategy for nonculprit vessels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The information of clinical trial registration for CCC\u2010ACS project can be found at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/study\/NCT02306616\">http:\/\/clinicaltrials.gov\/study\/NCT02306616<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31332","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:59:04Z","timestamp":1733885944000},"page":"43-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Multivessel Versus Culprit\u2010Vessel\u2010Only Revascularization in Patients With STEMI and Multivessel Disease During Primary PCI: In\u2010Hospital Outcomes From the CCC\u2010ACS Project in China"],"prefix":"10.1002","volume":"105","author":[{"given":"Tinghao","family":"Zhao","sequence":"first","affiliation":[{"name":"National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology General Hospital of Northern Theater Command Shenyang Liaoning China"},{"name":"The General Hospital of Northern Theater Command Training Base for Graduate China Medical University Shenyang Liaoning 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