{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:10:15Z","timestamp":1758931815142,"version":"3.44.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The self\u2010expanding, supra\u2010annular Evolut valve is an established platform for Transcatheter Aortic Valve Implantation (TAVI). Evolut PRO introduced an outer sealing wrap to mitigate paravalvular leakage. We evaluated the 3\u2010year clinical outcomes and valve performance of the Evolut PRO in standard clinical practice for severe aortic stenosis (AS) patients at intermediate or higher risk for surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The FORWARD PRO prospective, single\u2010arm, multicentre, post\u2010market clinical study enrolled 638 patients with native aortic valve stenosis or failed surgical bioprosthetic aortic valve undergoing TAVI, at intermediate or high risk, with the Evolut PRO valve. Clinical and serial echocardiographic outcomes were followed\u2010up for 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TAVI using Evolut PRO was attempted in 629 AS patients (implanted in 97%) (mean age 81.7 years; STS PROM score, 4.7%). At 3 years all\u2010cause mortality was 25.0%, disabling stroke 6.5% (all\u2010cause mortality or disabling stroke, 28.5%) and rate of new permanent pacemaker implantation 24.7%. Excellent valve haemodynamics were maintained (mean gradient 8.8\u2009\u00b1\u20094.7\u2009mm Hg; mean effective orifice area 2.0\u2009\u00b1\u20090.5\u2009cm<jats:sup>2<\/jats:sup>) at 3 years. In a paired analysis of patients with \u2265\u2009mild paravalvular leakage (PVL) at discharge, more than two\u2010thirds demonstrated improved PVL at 3 years. Patients with \u2265\u2009mild PVL at discharge had higher median total calcium volume than those with no\/trace PVL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In clinical practice TAVI with the Evolut PRO valve is associated with favorable clinical outcomes and excellent haemodynamic performance out to 3 years. The observation of improvements in PVL over time warrants further research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31335","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T01:53:34Z","timestamp":1734400414000},"page":"577-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three\u2010Year Outcomes With a Supra\u2010Annular, Self\u2010Expanding Bioprosthesis and a Pericardial Wrap\u2014The FORWARD PRO Study"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-1205","authenticated-orcid":false,"given":"Nicolas M.","family":"Van Mieghem","sequence":"first","affiliation":[{"name":"Department of Cardiology Cardiovascular Institute, Erasmus University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital Bern University Hospital Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Regional Health Centre, Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Lancellotti","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Liege Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"Cardiothoracic, Transplantation and Vascular Surgery Department Azienda Policlinico\u2010Vittorio Emanuele, Universita di Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-8253","authenticated-orcid":false,"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Cardiology Division Rabin Medical Center Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiology Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haim","family":"Danenberg","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Wolfson Medical Center Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fiorina","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department Spedali Civili di Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Scholtz","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology, Angiology Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen, Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Brecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saint George's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Ruge","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Deutsches Herzzentrum M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Opdahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Amoroso","sequence":"additional","affiliation":[{"name":"Department of Cardiology OLVG Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4975-6605","authenticated-orcid":false,"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Clinical Cardiology, Inverventional Cardiology and Coronary Intesive Care Units IRCCS Policlinico San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Sonia","family":"Petronio","sequence":"additional","affiliation":[{"name":"CardioThoracic and Vascular Department University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Heart Center Bonn University Hospital Bonn Bonn 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