{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:10:40Z","timestamp":1740103840335,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Short\u2010term percutaneous mechanical circulatory support (MCS) devices provide hemodynamic support in cardiogenic shock or during high\u2010risk percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the impact of age on the clinical and angiographic characteristics and in\u2010hospital outcomes of all patients undergoing PCI with the Impella MCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on all patients that underwent PCI with an Impella was divided into three groups according to age: &lt;\u200965, 65 to &lt;\u200975 years, and \u2265\u200975 years. In\u2010hospital mortality, stroke, and major bleeding complications were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2010 and 2018, 245 patients underwent PCI with Impella support. Almost half of all patients were &lt;\u200965 years old and 32% were \u2265\u200975 year old. Clinical characteristics varied significantly among the three groups. Almost half of younger patients were in the midst of an ST\u2010elevation myocardial infarction (STEMI) compared with 9% of patients \u2265\u200975 years (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Furthermore, 57% of younger patients were in cardiogenic shock, compared with 21% of those \u2265\u200975 years (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). In\u2010hospital mortality was highest in the 65 to &lt;\u200975 years group (17%) compared with 9% and 10% in the &lt;\u200965 and \u2265\u200975\u2010year\u2010olds groups, respectively. Major bleeding complications were not significantly different among the three age groups. Multivariable analysis for in\u2010hospital mortality showed that STEMI on presentation and ages 65 to &lt;\u200975 years compared to those &lt;\u200965 years were associated with an increased odds of in\u2010hospital death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical characteristics and indications for Impella MCS use in patients undergoing PCI varied significantly according to age. However, in\u2010hospital outcomes were not significantly different among the three groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31350","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:45:42Z","timestamp":1734000342000},"page":"517-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Age in Patients Undergoing Impella\u2010Assisted Percutaneous Coronary Interventions"],"prefix":"10.1002","volume":"105","author":[{"given":"Tia","family":"Bimal","sequence":"first","affiliation":[{"name":"Northwell, New Hyde Park &amp; Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Mather Hospital Port Jefferson New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Fishbein","sequence":"additional","affiliation":[{"name":"Office of Academic Affairs Northwell Health New Hyde Park New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Gandotra","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park &amp; Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"South Shore University Hospital Bay Shore New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-4666","authenticated-orcid":false,"given":"Perwaiz M.","family":"Meraj","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park &amp; Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"North Shore University Hospital Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Lee","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park &amp; Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Long Island Jewish Medical Center New Hyde Park New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park &amp; Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Lenox Hill Hospital New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wally","family":"Omar","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park &amp; Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Office of Academic Affairs Northwell Health New Hyde Park New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Ong","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park &amp; Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Office of Academic Affairs Northwell Health New Hyde Park New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1895-7460","authenticated-orcid":false,"given":"Luis","family":"Gruberg","sequence":"additional","affiliation":[{"name":"Northwell, New Hyde Park &amp; 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