{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:13:36Z","timestamp":1793218416599,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intravascular ultrasound (IVUS) guidance during percutaneous coronary intervention (PCI) allows better assessment of coronary artery lesion characteristics than angiography alone. This systematic review and meta\u2010analysis aimed to comprehensively synthesize the available evidence regarding the efficacy of IVUS guidance compared to angiography\u2010guided PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search of major bibliographic databases from inception until April 2024 was conducted to identify randomized control trials (RCTs) comparing IVUS\u2010guided PCI versus angiography\u2010guided PCI. Risk ratios (RR) with their corresponding 95% confidence intervals (CI) were pooled using the random\u2010effects model, with a\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen RCTs were included with 9354 patients undergoing PCI. IVUS\u2010guided PCI was associated with a lower risk of cardiac death [RR 0.49, 95% CI 0.33 to 0.72], major adverse cardiovascular events (MACE) [RR 0.64, 95% CI 0.51 to 0.80], myocardial infarction [RR 0.74, 95% CI 0.59 to 0.94], stent thrombosis [RR 0.48, 95% CI 0.29 to 0.81], target lesion revascularization [RR 0.60, 95% CI 0.48 to 0.75], and target vessel revascularization [RR 0.54, 95% CI 0.43 to 0.69] compared to angiography\u2010guided PCI. IVUS\u2010guided PCI was associated with a nonsignificant trend toward a reduced risk of all\u2010cause mortality [RR 0.82, 95% CI 0.58 to 1.01]. Meta\u2010regression showed a nonsignificant moderating effect of the duration of follow\u2010up, age of patients, diabetes mellitus, and acute coronary syndrome presentation of patients on pooled outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IVUS\u2010guided PCI reduced cardiac death, MACE, myocardial infarction, stent thrombosis, target lesion revascularization, and target vessel revascularization compared to angiography\u2010guided PCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31352","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T13:53:27Z","timestamp":1733925207000},"page":"68-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intravascular Ultrasound\u2010Guided Versus Angiography\u2010Guided Percutaneous Coronary Intervention: A Systematic Review, Meta\u2010Analysis, and Meta\u2010Regression of Randomized Control Trials"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-8224","authenticated-orcid":false,"given":"Mushood","family":"Ahmed","sequence":"first","affiliation":[{"name":"Rawalpindi Medical University Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5968-4538","authenticated-orcid":false,"given":"Zain Ali","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Allama Iqbal Medical College Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeba","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Foundation University Medical College Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Javaid","sequence":"additional","affiliation":[{"name":"Allama Iqbal Medical College Lahore 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