{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:08:38Z","timestamp":1774026518736,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intravascular ultrasound (IVUS)\u2010guided optimization of suboptimal fractional flow reserve (FFR) following percutaneous coronary intervention (PCI) results in a significant increase in both post\u2010PCI FFR and minimal lumen and stent areas (MLA and MSA, respectively). However, the impact of clinical presentation with non\u2010ST\u2010segment elevation acute coronary syndrome (NSTE\u2010ACS) versus chronic coronary syndrome (CCS) on the efficacy of PCI optimization remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prespecified subgroup analysis of the FFR REACT trial comparing IVUS\u2010guided PCI optimization versus no further treatment in 291 patients with a post\u2010PCI FFR\u2009&lt;\u20090.90. Post\u2010PCI physiology and pre optimization IVUS findings were compared between patients presenting with NSTE\u2010ACS versus CCS, as well as optimization strategy, final FFR and IVUS findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 291 patients, 130 (44.7%) presented with NSTE\u2010ACS. Median post\u2010PCI FFR was similar in patients with NSTE\u2010ACS and CCS (0.85 for both,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.55). Pre optimization IVUS findings did not differ significantly between both groups and subsequent optimization strategy was comparable (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.71). In both NSTE\u2010ACS and CCS, optimization resulted in a significant increase (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 for all) of similar magnitude in median FFR (0.02 vs. 0.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.80), MLA (0.37 vs. 0.50\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.46) and MSA (0.29 vs. 0.32 mm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.61), respectively. The clinical impact of IVUS\u2010guided optimization on 2\u2010year target vessel failure showed no signs of heterogeneity based on clinical presentation (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.36).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients undergoing FFR\u2010directed IVUS\u2010guided optimization, post\u2010PCI FFR, pre optimization IVUS findings and optimization strategy did not differ significantly between patients presenting with either NSTE\u2010ACS or CCS, with comparable improvements in FFR, MLA and MSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31357","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T02:35:17Z","timestamp":1735180517000},"page":"12-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fractional Flow Reserve Directed Percutaneous Coronary Intervention Optimization Using High\u2010Definition Intravascular Ultrasound in Non\u2010ST\u2010Segment Elevation Acute Coronary Syndrome Versus Chronic Coronary Syndrome"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-2042","authenticated-orcid":false,"given":"Frederik T. W.","family":"Groenland","sequence":"first","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Neleman","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke C.","family":"Ziedses des Plantes","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Scoccia","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Kardys","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wijnand K.","family":"den Dekker","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen M.","family":"Wilschut","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-6705","authenticated-orcid":false,"given":"Roberto","family":"Diletti","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-1205","authenticated-orcid":false,"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-1410","authenticated-orcid":false,"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of (Interventional) Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020547.92091.76"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.02.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.005233"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.07.031"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00913"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009681"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.32842"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.046"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015073"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab449"},{"issue":"2","key":"e_1_2_9_12_1","article-title":"Explanation of Postprocedural Fractional Flow Reserve Below 0.85","volume":"12","author":"Zandvoort L. 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