{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:53:43Z","timestamp":1764240823768,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The co\u2010existence of severe aortic stenosis (AS) and hypertrophic cardiomyopathy (HCM) is not uncommon. Surgical intervention is the gold standard management. Patients with high surgical risk might undergo transcatheter aortic valve replacement (TAVR). However, TAVR outcomes are unclear in this population. We aimed to investigate the impact of HCM on the outcomes of TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aim to investigate the outcomes of TAVR in patients with HCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched PubMed, EMBASE, and Scopus for studies that compared outcomes of TAVR procedure between patients with HCM and those without it. Using the random\u2010effects model, the odds ratios (OR) with 95% confidence interval (CI) were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We screened 102 articles and identified three observational cohort studies. Compared to patients who underwent TAVR without underlying HCM, TAVR for AS co\u2010existed with HCM was associated with higher rates of mortality (OR 5.79; 95% CI: 3.38; 9.91, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), cardiogenic shock (OR 4.55; 95% CI: 3.40; 6.08, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), aortic dissection (OR 4.95; 95% CI: 3.17; 7.74, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), vascular complications (OR 2.10; 95% CI: 1.27; 3.47, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), and renal impairment (OR 1.80; 95% CI: 1.36; 2.40, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). There was no difference between the comparison groups in terms of complete heart block, new permanent pacemaker implantation, or bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with severe AS and HCM, TAVR was associated with significantly higher occurrence of mortality, cardiogenic shock, aortic dissection, vascular complications, and renal impairment as well as the need for mechanical ventilation than patients who did not have HCM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31367","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:48:25Z","timestamp":1735868905000},"page":"754-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-2559","authenticated-orcid":false,"given":"Ashraf","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Bridgeport Hospital, Yale New Haven Health Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-9759","authenticated-orcid":false,"given":"Rasha","family":"Kaddoura","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Heart Hospital, Hamad Medical Corporation Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bridgeport Hospital, Yale New Haven Health Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tawanda","family":"Zinyandu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bridgeport Hospital, Yale New Haven Health Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Webber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bridgeport Hospital, Yale New Haven Health Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Davila","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Bridgeport Hospital, Yale New Haven Health Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Zarich","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Bridgeport Hospital, Yale New Haven Health Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"A.RobertaandS.Comenale 2023 Epidemiology of Aortic Valve Stenosis (AS) and of\u00a0Aortic Valve Incompetence (AI): Is the Prevalence of AS\/AI Similar in Different Parts of the World? Vol. 18 http:\/\/www.escardio.org\/Journals\/E-Journal-of-Cardiology-Practice\/Volume-18\/epidemiology-of-aortic-valve-stenosis-as-and-of-aortic-valve-incompetence-ai."},{"volume-title":"StatPearls [Internet]","year":"2023","author":"Pujari S. H.","key":"e_1_2_11_3_1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.05.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018435"},{"issue":"5","key":"e_1_2_11_6_1","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto C. 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