{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:30:07Z","timestamp":1790616607207,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The therapeutic management of patients with multivessel disease and severe left ventricular dysfunction is complex and controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to analyze the clinical outcomes and the changes in left ventricular ejection fraction (LVEF) in patients with severe left ventricular dysfunction and at least one chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI) with hemodynamic support provided by Impella.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, multicenter study enrolling patients with severe left ventricular dysfunction and severe coronary artery disease with at least one CTO who required percutaneous mechanical circulatory support with Impella, from January 2019 to December 2023. The primary endpoints were the incidence of MACE (composite of cardiovascular death, acute myocardial infarct, and target lesion revascularization) at 90 days. The secondary endpoint was changes in LVEF and functional class during the same period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 27 patients (34 CTOs) were included in the study. The mean SYNTAX score was 35\u2009\u00b1\u200911. The median J\u2010CTO score of 2 (1\u20133). At 90 day of follow\u2010up, there were three MACE (11%), two cardiovascular deaths and one TLR; three vascular complications were related to access for the Impella device (only one required invasive treatment); and LVEF improved significantly after revascularization (delta LVEF: 10% [CI 95% 6, 15]). A total of 81% of patients improved their angina or dyspnea status at 90 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In high\u2010risk patients with severe left ventricular dysfunction with complex coronary disease including CTO, PCI with mechanical circulatory support using the Impella device is associated with favorable safety and efficacy outcomes at short\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31392","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T03:10:06Z","timestamp":1736305806000},"page":"883-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mechanical Circulatory Support With Impella in High\u2010Risk Patients With Chronic Total Occlusion and Complex Multivessel Disease"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-5685","authenticated-orcid":false,"given":"Ignacio","family":"Gallo","sequence":"first","affiliation":[{"name":"Cardiology Department Reina Sofia University Hospital Cordoba Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-0360","authenticated-orcid":false,"given":"Lorenzo","family":"Azzalini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Gonz\u00e1lez\u2010Manzanares","sequence":"additional","affiliation":[{"name":"Cardiology Department Reina Sofia University Hospital Cordoba Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Cordoba 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