{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:25:33Z","timestamp":1770279933167,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data exist on the impact of polyvascular disease (PolyVD) on clinical outcomes in female patients undergoing transcatheter aortic valve replacement (TAVR). We therefore sought to investigate clinical outcomes in women with versus without PolyVD undergoing TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female participants from the multicentre Women's International Transcatheter Aortic Valve Implantation (WIN\u2010TAVI) registry were categorized based on the presence or absence of PolyVD. The PolyVD population was defined as the presence of atherosclerotic disease affecting\u2009\u2265\u20092 arterial systems from coronary, cerebral, or lower limb peripheral vessels, whilst patients with either no atherosclerosis or atherosclerotic disease in one vascular system were included in the non\u2010PolyVD population. The primary endpoint was the Valve Academic Research Consortium\u20102 consensus (VARC\u20102) efficacy endpoint at 1 year, whilst secondary endpoints included VARC\u20102 safety events, VARC\u20102 major bleeding and major vascular complications. Cox regression analysis were computed adjusting for various cofounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 996 participants, 543 (54.5%) had PolyVD, while 453 (45.5%) did not. Across the subgroups no differences in age was noted, whilst patients with PolyVD were more likely to have a history of hypercholesterolemia and a previous cardiac surgery. The incidence of the primary endpoint was higher in the PolyVD group (19.4%) compared to the non\u2010PolyVD group (13.3%, <jats:italic>p<\/jats:italic><jats:sub>log\u2010rank<\/jats:sub>\u2009=\u20090.014), though the difference was attenuated after multivariable adjustments (<jats:italic>p<\/jats:italic>\u2009=\u20090.093). Of note, no statistically significant differences concerning incident VARC\u20102 safety events, VARC\u20102 major bleeding and major vascular complications were noted according to PolyVD status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PolyVD is a common comorbidity and is associated with elevated rates of adverse clinical events, but no increase in safety events, vascular complications, or bleeding among women undergoing TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31395","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:44:54Z","timestamp":1736343894000},"page":"891-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes According to the Extent of Atherosclerotic Disease in Female Patients Undergoing Transcatheter Aortic Valve Replacement: An Analysis From the WIN\u2010TAVI Registry"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-8033","authenticated-orcid":false,"given":"Benjamin","family":"Bay","sequence":"first","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Cardiology, University Heart &amp; Vascular Center Hamburg University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Gitto","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-9409","authenticated-orcid":false,"given":"Samantha","family":"Sartori","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Vogel","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Tchetche","sequence":"additional","affiliation":[{"name":"Clinique Pasteur Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Sonia","family":"Petronio","sequence":"additional","affiliation":[{"name":"AOUP Cisanello University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julinda","family":"Mehilli","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Landshut\u2010Achdorf Hospital Landshut Germany"},{"name":"Klinikum der Universit\u00e4t M\u00fcnchen Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Maria","family":"Di Muro","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Structural Interventional Cardiology, Department of Clinical and Experimental Medicine Clinica Medica, Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lefevre","sequence":"additional","affiliation":[{"name":"Institut Hospitalier Jacques Cartier, Ramsay G\u00e9n\u00e9rale de Sant\u00e9 Massy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Presbitero","sequence":"additional","affiliation":[{"name":"Istituto Clinico Humanitas Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8434-7367","authenticated-orcid":false,"given":"Piera","family":"Capranzano","sequence":"additional","affiliation":[{"name":"Cardiology, Policlinico Hospital University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-7563","authenticated-orcid":false,"given":"Angelo","family":"Oliva","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-1155","authenticated-orcid":false,"given":"Alessandro","family":"Iadanza","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-4760","authenticated-orcid":false,"given":"Pier Pasquale","family":"Leone","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-9479","authenticated-orcid":false,"given":"Gennaro","family":"Sardella","sequence":"additional","affiliation":[{"name":"Policlinico Umberto I \u201cSapienza,\u201d University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-1205","authenticated-orcid":false,"given":"Nicolas M.","family":"van Mieghem","sequence":"additional","affiliation":[{"name":"Thoraxcentre, Erasmus University Medical Center Rotterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Division of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Meliga","sequence":"additional","affiliation":[{"name":"Mauriziano Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Feng","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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