{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:39:08Z","timestamp":1754145548671,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objective of this study is to determine if cardiac damage based on hospital discharge codes is associated with in\u2010hospital outcomes in patients with aortic stenosis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of hospital admissions between 2016 and 2021 with a diagnosis of AS in the National Inpatient Sample (NIS). The cardiac damage stages 0\u22124 were determined based on hospital discharge codes. Logistic and linear regressions were used to determine the association between cardiac stage and in\u2010hospital mortality, length of stay (LoS) and cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,980,150 hospital admissions were included in the analysis (82.5% conservative management, 11.2% transcatheter aortic valve replacement [TAVR], 6.3% surgical aortic valve replacement [SAVR]). The association between cardiac damage stage and in\u2010hospital outcome was most significant for patients who had SAVR treatment (stage 4 vs. stage 0: mortality OR 27.70 95% CI 17.35\u221235.17, LoS 7.34 95% CI 6.34\u22128.35, cost 70,710 95% CI 65,110\u221276,310) compared to TAVR treatment (stage 4 vs. stage 0: mortality OR 9.15 95% CI 5.52\u221215.15, LoS 6.27 95% CI 5.63\u22126.90, cost 28,384 25,084 to 31,684) and conservative treatment (stage 4 vs. stage 0: mortality OR 3.55 95% CI 3.13\u22124.04, LoS 2.09 95% CI 1.87 to 2.31, cost 6362 95% CI 5642\u22127083).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiac damage can be evaluated using diagnostic codes in patients with AS and it is associated with in\u2010hospital mortality, LoS and cost, and has more impact on these outcomes in patients treated with SAVR versus those treated with TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31399","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T01:49:17Z","timestamp":1736128157000},"page":"795-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Cardiac Damage on In\u2010Hospital Outcomes for Patients With Aortic Stenosis in the United States: An Analysis From The National Inpatient Sample"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-1586","authenticated-orcid":false,"given":"Chun Shing","family":"Kwok","sequence":"first","affiliation":[{"name":"Department of Cardiology Mid Cheshire Hospitals NHS Foundation Trust Crewe UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadie","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of North Midlands NHS Trust Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithilesh","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of North Midlands NHS Trust Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan I.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institute and Department of Neurology University of Missouri\u2010Columbia Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of North Midlands NHS Trust Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anikethana","family":"Appaji","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of North Midlands NHS Trust Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Holroyd","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of North Midlands NHS Trust Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Laval University Quebec Canada"},{"name":"Quebec Heart and Lung Institute  Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjorn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Gothenburg University  Sweden"},{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Clinical trials Centre, Cardiovascular Research Foundation New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-3712","authenticated-orcid":false,"given":"Philippe","family":"Genereux","sequence":"additional","affiliation":[{"name":"Gagnon Cardiovascular Institute, Morristown Medical Center Morristown New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194563"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERP-20-0035"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60211-7"},{"issue":"18","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287508","article-title":"Impact of Severe Aortic Stenosis on Quality of Life","volume":"21","author":"Gracia Baena J. 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