{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T01:54:49Z","timestamp":1781056489574,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The super high\u2010pressure NC balloon (OPN NC; SIS Medical AG, Winterthur, Switzerland) is increasingly used in percutaneous coronary intervention (PCI). We performed a systematic review and meta\u2010analysis of its efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted using PubMed and the Cochrane Library to identify studies using the OPN NC balloon in PCI. Procedural success, major adverse cardiac events (MACE), coronary perforation, and other complications were pooled using weighted means, confidence intervals (CI), and <jats:italic>I<\/jats:italic>\u00b2 statistics for heterogeneity assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine studies (5 prospective including 2 randomized\u2010controlled trials, 12 retrospective, and 12 case reports) were included in the systematic review, of which 11 (3 prospective, 8 retrospective) were included in the meta\u2010analysis. Of the 1015 meta\u2010analysis patients, 50.7% presented with stable angina and 21.6% with an acute coronary syndrome. Mean lesion length was 22.8\u2009\u00b1\u200913.7\u2009mm, the prevalence of moderate or severe calcification was 93.7%, and 40.4% of lesions were in\u2010stent. Procedural success was 95.1% (95% CI 89.3%\u221298.8% with significant heterogeneity: <jats:italic>I<\/jats:italic>\u00b2 = 84.9%). The incidence of periprocedural MACE was 1.9% (95% CI 1.1%\u22122.8%, <jats:italic>I<\/jats:italic>\u00b2 86.9%), and the incidence of coronary perforation was 0.6% (95% CI 0.3%\u22121.5%, <jats:italic>I<\/jats:italic>\u00b2 87.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of the OPN NC balloon is associated with high success and acceptable complication rates. The heterogeneity of outcomes underscores the need for additional studies and standardized definitions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31403","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T01:49:34Z","timestamp":1736819374000},"page":"938-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systematic Review and Meta\u2010Analysis of the Super High\u2010Pressure Balloon (SIS\u2010OPN) for Percutaneous Coronary Intervention"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-3682","authenticated-orcid":false,"given":"Sant","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Cardiology Creighton University School of Medicine Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Jalli","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-2972","authenticated-orcid":false,"given":"Yader","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaldoon","family":"Alaswad","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease Henry Ford Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-7568","authenticated-orcid":false,"given":"Nachiket J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chandler Regional Medical Center Chandler Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-0533","authenticated-orcid":false,"given":"Tim","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Carl and Edyth Lindner Center for Research and Education Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Doshi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Pershad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chandler Regional Medical Center Chandler Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Seto","sequence":"additional","affiliation":[{"name":"Division of Cardiology VA Long Beach Healthcare System, Long Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-846X","authenticated-orcid":false,"given":"Gautam","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Nicholas","family":"Burke","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-9701","authenticated-orcid":false,"given":"Emmanouil S.","family":"Brilakis","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-726x(200102)52:2<164::aid-ccd1041>3.0.co;2-s"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"168","article-title":"Cutting Balloon Entrapment During Treatment of In\u2010Stent Restenosis: An Unusual Complication and Its Management","volume":"17","author":"Giugliano G. 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