{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T09:22:05Z","timestamp":1777800125169,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evaluating health status changes following transfemoral carotid artery stenting (TF\u2010CAS) is essential for assessing procedural success, but meaningful clinical changes are unknown. We aimed to determine minimal clinically important differences (MCIDs) and quantify health status improvement or worsening rates after TF\u2010CAS using the Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) registry data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SAPPHIRE registry included patients undergoing TF\u2010CAS from 2010 to 2014 for both symptomatic and asymptomatic carotid stenosis. Baseline and 30\u2010day health status were assessed using the SF\u201036 (2010\u20132012) for mental and physical component scores (MCS and PCS) and the EQ\u20105D (2012\u20132014) for 3\u2009L Index and Visual Analog Scale (VAS) scores. For each score, we calculated the 30\u2010day distribution\u2010based MCID (0.5*standard deviations of baseline health status) by symptom status and the overall cohort (symptom\u2010weighted MCIDs). The changes were then categorized as improved, deteriorated, or unchanged based on these MCIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Health status was assessed using the EQ\u20105D in 3930 patients and the SF\u201036 in 3018 patients (27.7% and 30.5% symptomatic, respectively). The MCIDs by symptom status were close, hence weighted MCIDs of 0.09 (Index), 11.00 (VAS), 4.70 (PCS), and 5.40 (MCS) were established. Across all subscales, 21.2%\u201326.1% of patients improved, 10.5%\u201316.7% worsened, and 57.2%\u201366.1% unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We established thresholds for meaningful health status changes after TF\u2010CAS using common generic instruments. At 30 days after TF\u2010CAS, 70%\u201380% of patients no change or worsened, while 20%\u201330% improved. Carotid artery disease\u2010specific instrument would provide better insights into of TF\u2010CAS effects on health status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31410","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T23:54:14Z","timestamp":1736466854000},"page":"927-937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Defining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting"],"prefix":"10.1002","volume":"105","author":[{"given":"Jonathan","family":"Kluger","sequence":"first","affiliation":[{"name":"Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-5507","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Romain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Vascular Medicine Outcomes Program (VAMOS), Section of Cardiovascular Medicine, Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mena\u2010Hurtado","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Vascular Medicine Outcomes Program (VAMOS), Section of Cardiovascular Medicine, Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Grubman","sequence":"additional","affiliation":[{"name":"Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Pajarillo","sequence":"additional","affiliation":[{"name":"Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Cleman","sequence":"additional","affiliation":[{"name":"Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0589","authenticated-orcid":false,"given":"Lindsey","family":"Scierka","sequence":"additional","affiliation":[{"name":"Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6104-6254","authenticated-orcid":false,"given":"Kim G.","family":"Smolderen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Vascular Medicine Outcomes Program (VAMOS), Section of Cardiovascular Medicine, Yale School of Medicine New Haven Connecticut USA"},{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-7490"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16146-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530190019015"},{"issue":"2","key":"e_1_2_9_6_1","article-title":"Carotid Artery Stenting Versus Endarterectomy for Treatment of Carotid Artery Stenosis","volume":"2","author":"Muller M. 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