{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T12:00:02Z","timestamp":1752667202050,"version":"3.40.3"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biodegradable polymer stents may reduce the risk of neoatherosclerosis and stent thrombosis. Limited data is available for biodegradable polymer sirolimus\u2010eluting stent (BP\u2010SES) and durable polymer drug\u2010eluting stents (DP\u2010EES) in chronic total occlusions (CTO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study was to evaluate healing patterns of BP\u2010SES versus DP\u2010EES in CTO at 3 and 13 months based on optical coherence tomography (OCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The TARGET\u2010CTO study is a prospective, multicenter, randomized noninferiority controlled trial for BP\u2010SES compared to DP\u2010EES in CTO. In the current predefined subanalysis, 44 consecutive patients underwent OCT follow\u2010up at 3 and 13 months. The primary endpoint was mean neo\u2010intimal thickness at 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3 months, mean neo\u2010intimal thickness was 47.6\u2009\u00b1\u200915.7\u2009\u00b5m in BP\u2010SES and 62.5\u2009\u00b1\u200937.3\u2009\u00b5m in DP\u2010EES (<jats:italic>p<\/jats:italic>\u2009=\u20090.384), meeting the noninferiority for BP\u2010SES (<jats:italic>p<\/jats:italic><jats:sub>noninferiority<\/jats:sub>\u2009&lt;\u20090.001). Mean neo\u2010intimal thickness at 13 months was 76.4\u2009\u00b1\u200934.1\u2009\u00b5m in BP\u2010SES and 106.6\u2009\u00b1\u200954.9\u2009\u00b5m in DP\u2010EES (<jats:italic>p<\/jats:italic>\u2009=\u20090.086). No significant differences in strut coverage were observed at 3 or 13 months. At 13 months significantly higher percentages of frames with layered neo\u2010intima and neoatherosclerosis were observed in DP\u2010EES compared to BP\u2010SES (<jats:italic>p<\/jats:italic>\u2009=\u20090.015 and <jats:italic>p<\/jats:italic>\u2009=\u20090.021, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BP\u2010SES was noninferior to DP\u2010EES in terms of neo\u2010intimal thickness at 3 months and healing responses at 3\u2010month follow\u2010up were comparable. At 13 months, less advanced neoatherosclerosis patterns were observed in BP\u2010SES as compared to DP\u2010EES.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31423","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:39:57Z","timestamp":1738157997000},"page":"1124-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vascular Healing After Biodegradable Polymer Sirolimus\u2010Eluting Versus Durable Polymer Everolimus\u2010Eluting Stents in Chronic Total Occlusions"],"prefix":"10.1002","volume":"105","author":[{"given":"Geng","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Frigid Zone Cardiovascular Diseases, Cardiovascular Research Institute and Department of Cardiology General Hospital of Northern Theater Command Shenyang 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