{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:01:27Z","timestamp":1762300887409,"version":"3.40.3"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The changes over time and effects on long\u2010term clinical outcomes beyond 1 year of irregular protrusion (IP) in chronic coronary syndrome (CCS) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to assess the time\u2010dependent change and long\u2010term clinical impact of IP in CCS lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a post hoc analysis of COLLABORATION study, which was a multicenter, prospective, observational study conducted from July 2018 to February 2020, assessing 1\u2010 and 12\u2010month serial vessel responses after stent implantation using OCT and coronary angioscopy. Time\u2010dependent change in the presence of IP was evaluated using the serial OCT examinations. The cumulative 3\u2010year incidence of TLR was compared between the lesions with and without IP, as well as between those with and without residual IP at 1 month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 107 lesions, IP was detected in post\u2010OCT pullbacks in 38 (35.5%) lesions. Out of the 38 lesions, IP remained in 9 (23.7%) lesions at 1 month and existed in 2 (5.3%) lesions at 12 months. The cumulative 3\u2010year incidence of TLR was significantly higher in IP group than in non\u2010IP group (13.6% vs. 3.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Similarly, it was significantly higher in lesions with residual IP at 1 month than those without (33.3% vs. 4.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). All residual IP at 1 month were composed of angioscopic yellow plaques and red thrombi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of IP decreased over time, but approximately one\u2010fourth of IP remained at 1 month. IP and residual IP at 1 month were important post\u2010stent OCT findings leading to long\u2010term TLR in patients with CCS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31430","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:34:51Z","timestamp":1738582491000},"page":"1149-1160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serial Change and Clinical Impact of Irregular Protrusion in Lesions With Chronic Coronary Syndrome"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-679X","authenticated-orcid":false,"given":"Naotaka","family":"Okamoto","sequence":"first","affiliation":[{"name":"Division of Cardiology Osaka Rosai Hospital Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isamu","family":"Mizote","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University 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