{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:41:20Z","timestamp":1774280480442,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). Data regarding its impact on mortality and morbidity are conflicting. This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health\u2010related Quality of Life (QoL) during the first year after TAVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, <jats:italic>n<\/jats:italic>\u2009=\u2009779), PPI before TAVI (PPI pre\u2010TAVI, <jats:italic>n<\/jats:italic>\u2009=\u2009102), PPI within 30 days after TAVI (PPI post\u2010TAVI, n\u2009=\u200997). All\u2010cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF\u201012 and EQ\u20105D\u20105L questionnaires at baseline and 3, 6, and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1\u2010year, all\u2010cause death was seen in 6.9% (PPI pre\u2010TAVI, <jats:italic>p<\/jats:italic>\u2009=\u20090.53) and 10.3% (PPI post\u2010TAVI, <jats:italic>p<\/jats:italic>\u2009=\u20090.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre\u2010TAVI, <jats:italic>p<\/jats:italic>\u2009=\u20090.58) and 6.2% (PPI post\u2010TAVI, <jats:italic>p<\/jats:italic>\u2009=\u20090.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre\u2010TAVI group showed lower PCS\u201012 over time compared to the no PPI group (<jats:italic>p<\/jats:italic>\u2009=\u20090.04), while MCS\u201012, EQ\u20105D Index and EQ\u20105D VAS scores were equal. No significant differences in QoL were seen between the PPI post\u2010TAVI group and the no PPI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre\u2010TAVI was associated with lower physical QoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31431","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T12:17:46Z","timestamp":1738153066000},"page":"1098-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-8448","authenticated-orcid":false,"given":"P. J. A.","family":"van Nuland","sequence":"first","affiliation":[{"name":"Faculty of Health, Medicine and Life Sciences (FHML) University Maastricht Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Halim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Elisabeth\u2010Tweesteden Hospital Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"van Ginkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1368-5499","authenticated-orcid":false,"given":"D. C.","family":"Overduin","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-1031","authenticated-orcid":false,"given":"J.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-7427","authenticated-orcid":false,"given":"V. J.","family":"Nijenhuis","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W. 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