{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T04:08:39Z","timestamp":1746677319815,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>One\u2010third of patients undergoing TAVR have a concomitant indication for oral anticoagulation. The impact of continuation as compared to interruption of oral anticoagulation during TAVR on health\u2010related quality of life is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the impact of continuation as compared to interruption of oral anticoagulation on health\u2010related quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The POPular PAUSE TAVI (Periprocedural Continuation vs<jats:italic>.<\/jats:italic> Interruption of Oral Anticoagulant Drugs during Transcatheter Aortic Valve Implantation) trial was an international, open\u2010label, randomized, clinical trial performed at 22 European sites. Health\u2010related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ) and Short Form\u201012 (SF\u201012) before, and at 1 and 3 months after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8 patients were included: 431 were assigned to continuation and 427 to interruption of oral anticoagulation. Before TAVR, the mean overall KCCQ summary score was 53.6 (\u00b126.0). At 1 month, the mean change in KCCQ summary score as compared to baseline was +11.4 points (95% confidence interval [CI] 8.0\u201314.8) in the continuation group and +12.2 points (95% CI 8.8\u201315.6) in the interruption group (difference \u22120.7 points; 95% CI \u22124.6 to 3.1). At 3 months, the mean change was +11.0 points (95% CI 7.3\u201314.6) versus +13.8 points (95% CI 10.2\u201317.4), respectively (difference \u22122.8 points; 95% CI \u22127.1 to 1.5). Mean changes in SF\u201012 physical and mental component summary scores showed no differences between both groups at 1 and 3 months after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing TAVR with a concomitant indication for oral anticoagulation, continuation as compared to interruption of oral anticoagulation during TAVR did not significantly impact health\u2010related quality of life up to 3 months after TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31457","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:41:41Z","timestamp":1740134501000},"page":"1329-1337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Continuation Versus Interruption of Oral Anticoagulation During TAVI on Health\u2010Related Quality of Life"],"prefix":"10.1002","volume":"105","author":[{"given":"Dirk Jan","family":"van Ginkel","sequence":"first","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem L.","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-8275","authenticated-orcid":false,"given":"Hugo M.","family":"Aarts","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam the Netherlands"},{"name":"Department of Cardiology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole De","family":"Backer","sequence":"additional","affiliation":[{"name":"The Heart Center, Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-7667","authenticated-orcid":false,"given":"Maxim J. P.","family":"Rooijakkers","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Rosseel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hartcentrum Aalst Aalst Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Veenstra","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center Maastricht the Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronak","family":"Delewi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurri\u00ebn M.","family":"ten Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"},{"name":"Department of Cardiology Maastricht University Medical Center Maastricht the Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2012.03.075"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMACARDIO.2017.2039"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2019.09.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.010258"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12872-023-03445-Y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/HEX.12393"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007546"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCIN.2018.11.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-021-01638-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCIN.2023.10.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/CCD.31218"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2022.05.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2407794"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHY136"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CHEST.2022.07.025"},{"key":"e_1_2_8_19_1","unstructured":"Richtlijn Antitrombotisch beleid. 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