{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:56:02Z","timestamp":1783436162813,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dual antiplatelet therapy (DAPT) for 1 year after acute coronary syndrome (ACS) in patients undergoing percutaneous coronary intervention (PCI) with drug\u2010eluting stents (DES) is the standard of care. However, it is associated with a higher incidence of bleeding events. We conducted a systematic review and meta\u2010analysis of randomized controlled trials (RCTs) to assess the safety and efficacy of short\u2010term DAPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to assess the relative risk of major and minor bleeding, net adverse clinical and cerebral events (NACCE), and all\u2010cause mortality in patients with ACS undergoing PCI with DES, comparing ticagrelor\u2010based short\u2010term DAPT (\u2264\u20093 months) followed by ticagrelor monotherapy for up to 12 months versus 12\u2010month DAPT. The secondary endpoint evaluated the relative risk of complications, including myocardial infarction, stroke, stent thrombosis, repeat revascularization, and cardiovascular mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of PubMed, Scopus, and Cochrane Central was conducted for eligible RCTs. A subgroup analysis of ultrashort\u2010term DAPT (\u2264\u20091 month) followed by ticagrelor monotherapy for up to 12 months was also performed. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five RCTs were included with a total of 21,407 patients. Short\u2010term DAPT was associated with a significant reduction in major bleeding (RR 0.50; 95% CI 0.38\u22120.66; <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.01), minor bleeding (RR 0.53; 95% CI 0.35\u22120.80; <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.01), NACCE (RR 0.71; 95% CI 0.59\u22120.85; <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.01), and all\u2010cause mortality (RR 0.78; 95% CI 0.62\u22120.98; <jats:italic>p\u2009<\/jats:italic>=0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010term DAPT followed by ticagrelor monotherapy up to 12 months was associated with a significant reduction in major and minor bleeding, NACCE, and all\u2010cause mortality compared to 12\u2010month DAPT. There were no significant differences in myocardial infarction, stroke, stent thrombosis, repeat revascularization, or cardiovascular mortality. Major bleeding and NACCE remained consistently reduced in the subgroup analysis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31459","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T15:29:06Z","timestamp":1741447746000},"page":"1381-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ticagrelor Monotherapy Following Short\u2010Term DAPT in ACS Undergoing PCI: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8849-4552","authenticated-orcid":false,"given":"Rocio Barriga","family":"Guzman","sequence":"first","affiliation":[{"name":"Advocate Illinois Masonic Medical Center Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Villegas","family":"Roberson","sequence":"additional","affiliation":[{"name":"Advocate Illinois Masonic Medical Center Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7714-7148","authenticated-orcid":false,"given":"Larissa","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Federal University of Campina Grande Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denilsa D. P.","family":"Navalha","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Talavera","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center Miami Beach USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Advocate Illinois Masonic Medical Center Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Chatzizisis","sequence":"additional","affiliation":[{"name":"University of Miami, Division of Cardiovascular Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-1459","authenticated-orcid":false,"given":"Nikolaos","family":"Spilias","sequence":"additional","affiliation":[{"name":"University of Miami, Division of Cardiovascular Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001038"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00473-2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066943"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015560"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa670"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7580"},{"key":"e_1_2_12_11_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.4","author":"Higgins J. 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