{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T04:08:39Z","timestamp":1746677319589,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Standard of care (SoC) assessment based on computed tomography (CT) and\/or transesophageal echocardiography is suboptimal for adequate preprocedural evaluation for left atrial appendage occlusion (LAAO). This can be improved through CT\u2010based 3D computational modeling of the LAA\u2010device interaction using FEops HEARTguide. This study aims to assess the decisional impact of FEops in preprocedural planning for LAAO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PRECISE LAAO is a prospective multi\u2010center self\u2010controlled study evaluating the use of FEops in LAAO with Amulet. Preprocedural device size selection and degree of certainty (scale 0\u221210) were registered before (Decision SoC) and after accessing FEops (Decision FEops), followed by device implantation. Concordance was compared between the Decisions and the final implanted device. After the procedure, clinicians rated the subjective value of FEops on a scale from \u22123 (futile) to +3 (most helpful).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred two patients were included. Decision SoC was concordant with the implanted device in 61 patients (59.8%), whereas Decision FEops was concordant in 92 (90.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). FEops induced a size change in 35 patients, which was correct in 33 (32.4%). Certainty SoC was 6.7\u2009\u00b1\u20091.3 and increased after FEops assessment to 7.6\u2009\u00b1\u20091.3 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In the 33 patients with FEops\u2010induced positive corrections, Certainty SoC was lower (6.2\u2009\u00b1\u20091.5, suggesting a more complex procedure) and increased to 7.2\u2009\u00b1\u20091.2 with FEops (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). Clinicians rated FEops as helpful (subjective score\u2009\u2265\u20091) in 90.2% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT\u2010based computational modeling using FEops has a positive decisional impact in LAAO, inducing a change in Amulet size selection in almost one out of three patients and increasing procedural confidence.<\/jats:p><jats:p><jats:bold>Trials Trial Registration:<\/jats:bold> NCT04640051.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31464","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T07:01:34Z","timestamp":1740466894000},"page":"1356-1364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Value of CT\u2010Based 3D Computational Modeling in Left Atrial Appendage Occlusion: An In\u2010Depth Analysis of the PRECISE LAAO Study"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-6306","authenticated-orcid":false,"given":"Emmanuel","family":"De Cock","sequence":"first","affiliation":[{"name":"Department of Cardiology AZ Sint\u2010Jan Brugge AV Brugge Belgium"},{"name":"Department of Cardiology Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"Lochy","sequence":"additional","affiliation":[{"name":"Department of Cardiology UZ Brussel Brussel Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximo","family":"Rivero\u2010Ayerza","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg (ZOL) Genk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Lempereur","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHU de Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoff","family":"Cornelis","sequence":"additional","affiliation":[{"name":"Department of Cardiology AZ Maria Middelares Gent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Debonnaire","sequence":"additional","affiliation":[{"name":"Department of Cardiology AZ Sint\u2010Jan Brugge AV Brugge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-3453","authenticated-orcid":false,"given":"Paul","family":"Vermeersch","sequence":"additional","affiliation":[{"name":"Department of Cardiology ZNA Middelheim Antwerpen Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Christiaen","sequence":"additional","affiliation":[{"name":"Department of Cardiology AZ Sint\u2010Jan Brugge AV Brugge 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