{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T21:07:29Z","timestamp":1763500049078,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The potential for coronary artery compression (CC) during transcatheter pulmonary valve replacement (TPVR) using self\u2010expanding valves (SEV) is not fully understood, yet anecdotal reports suggest that this risk exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and Methods<\/jats:title><jats:p>We performed a retrospective cohort study of patients evaluated for SEV\u2010TPVR to evaluate the relationship between the right ventricular outflow tract (RVOT) and coronary arteries (CA). CT\u2010derived segmentations of the RVOT and CA were created using machine learning. A 2D map of the distance between the RVOT surface and CA, in systole and diastole, was created. In the subset of patients with post\u2010procedural CTA, the distance before and after TPVR was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two individuals underwent screening for SEV\u2010TPVR, of which 83% (<jats:italic>n<\/jats:italic>\u2009=\u200935) had SEV implanted (Harmony\u2009=\u200924; Alterra\u2009=\u200911). Median age was 22.9 years (range 12\u221260) and 76% had tetralogy of Fallot (TOF). There was no significant change in the distance between the RVOT and LCA between diastole and systole (<jats:italic>p<\/jats:italic>\u2009=\u20090.31), yet the RVOT area nearest to the LCA displaced proximally by 11\u2009mm (IQR: 5.6\u221219.9) in systole. In 8 patients with pre\u2010 and post\u2010TPVR CTA, no statistically significant differences were observed in the RVOT\u2010to\u2010LCA relation after intervention. The distance to the LCA was smaller in pulmonary stenosis\/atresia patients than those with TOF (median distance 1.2 and 2.1\u2009mm, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.185).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The RVOT area in closest proximity to LCA is dynamic and should be considered when planning TPVR. Special attention should be given to patients with a diagnosis of pulmonary stenosis\/atresia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31469","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:11:37Z","timestamp":1741745497000},"page":"1479-1485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Image\u2010Derived Modeling to Assess Coronary Proximity in Patients Undergoing Transcatheter Pulmonary Valve Replacement With Self\u2010Expanding Valves"],"prefix":"10.1002","volume":"105","author":[{"given":"Yuval","family":"Barak\u2010Corren","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav","family":"Obsekov","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The Mount Sinai Hospital New York New York USA"},{"name":"Hospital of the University of Pennsylvania University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-5897","authenticated-orcid":false,"given":"Mudit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Herz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvani","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andras","family":"Lasso","sequence":"additional","affiliation":[{"name":"Laboratory for Percutaneous Surgery Queen's University Kingston Ontario CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-1634","authenticated-orcid":false,"given":"Michael L.","family":"O'Byrne","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-0130","authenticated-orcid":false,"given":"Matthew A.","family":"Jolley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Department of Anesthesiology and Critical Care Medicine The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.02.052"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa167"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2022.06.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"C. 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H.Barocas \u201cFinite Element Modeling Using Patient\u2010Specific Geometry to Predict Aortic Valve Insufficiency During Percutaneous Pulmonary Valve Implantation \u201d Paper Presented at 2022 Design of Medical Devices Conference 2022.","DOI":"10.1115\/DMD2022-1022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000202"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674259"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26547"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq056"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-012-0005-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2024.102500"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.886549"},{"key":"e_1_2_10_14_1","article-title":"MONAI Label: A Framework for AI\u2010Assisted Interactive Labeling of 3D Medical Images","volume":"95","author":"Andres Diaz\u2010Pinto S. 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