{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:52:45Z","timestamp":1780591965238,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incidence and prognostic of unstable angina after high\u2010sensitivity troponin assesment is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study evaluated prognostic of a contemporary population of patients with UA defined using high sensitive T troponin (T hs\u2010cTn) measurements and with significant coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients admitted in 2 French university centres with UA defined as clinical ischemic symptoms and T hs\u2010cTn dosages undetectable (&lt;\u20095\u2009ng\/L), non\u2010elevated (&gt;\u200914\u2009ng\/L) or mildly elevated (14\u221250\u2009ng\/L) were included. The primary end\u2010point included major events at 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1752 patients admitted for ACS between December 2021 and February 2023, 210 (12.0%) have UA and significant CAD. Mean age was 66\u2009\u00b1\u200912 years, with predominantly men (<jats:italic>n<\/jats:italic>\u2009=\u2009143; 68.1%). Patients had undetectable (<jats:italic>n<\/jats:italic>\u2009=\u20094), non\u2010elevated (<jats:italic>n<\/jats:italic>\u2009=\u200980) or mildly elevated and stable T hs\u2010cTn (<jats:italic>n<\/jats:italic>\u2009=\u2009126). History of CAD was found in 98 patients (46.6%). Percutaneous intervention was required in main patients (<jats:italic>n<\/jats:italic>\u2009=\u2009186; 88.6%). Adverse non\u2010fatal in\u2010hospital event occurred in one patient. The primary outcome was achieved in 55 patients (26.2%; CI 95% [20.2\u221232.1]) mainly related to new ACS (<jats:italic>n<\/jats:italic>\u2009=\u200934, 16.2%). The level of troponin at admission (<jats:italic>p<\/jats:italic>\u2009=\u20090.639) was not associated with the primary outcome. In multivariate analysis, multiple risk factors (OR 1.93, [1.01\u22123.69], <jats:italic>p<\/jats:italic>\u2009=\u20090.0194), history of CAD (3.09; CI [1.63; 5.87], <jats:italic>p<\/jats:italic>\u2009=\u20090.0005), and tritroncular disease (OR 2.66; CI [1.24; 5.69], <jats:italic>p<\/jats:italic>\u2009=\u20090.0118) were significantly associated with major events at 1\u2010year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contemporary incidence of UA with significant CAD is low with few in\u2010hospital events, but with a 1\u2010year incidence of cardiac events high (26%), mainly related to new ACS. Improving secondary prevention may be crucial for these patients. (ID: NCT06378333).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31473","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:05:11Z","timestamp":1741680311000},"page":"1445-1452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence and 1\u2010Year Prognostic of Unstable Angina After High\u2010Sensitivity Troponin Assessment"],"prefix":"10.1002","volume":"105","author":[{"given":"Romain","family":"Jouen","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Alain","family":"Meunier","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Montpellier Montpellier 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