{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:07:19Z","timestamp":1771232839851,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited evidence on the safety and efficacy of biodegradable\u2010polymer sirolimus\u2010eluting ultra\u2010thin stent (BP\u2010SES) in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aims to evaluate the clinical outcomes of HBR patients treated with BP\u2010SES and \u2264\u200930\u2010day dual antiplatelet therapy (DAPT) regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted to identify relevant studies involving HBR patients who underwent PCI with BP\u2010SES (Supraflex Cruz). Individual patient\u2010level data were extracted from the included studies. The primary endpoint was the composite of cardiovascular death, myocardial infarction, or clinically driven target lesion revascularization at 1\u2010year. The safety endpoint was the 1\u2010year occurrence of Bleeding Academic Research Consortium (BARC) type 3\u22125.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 1691 patients. Of these, 928 patients (55%) received a\u2009\u2264\u200930\u2010day DAPT, while 763 patients (45%) received a longer DAPT regimen. In the \u2264\u200930\u2010day DAPT group, primary outcome events occurred in 89 patients (9.5%, 95% CI: 7.7%\u221211.6%). The upper limit of the one\u2010sided 95% CI of 11.6% was below the pre\u2010specified non\u2010inferiority margin of 14%. There was no significant difference in the primary endpoint between the \u2264\u200930\u2010day DAPT group and the &gt;30\u2010day DAPT group (propensity score adjusted HR: 0.95, 95% CI: 0.67\u22123). Notably, the incidence of BARC 3\u22125 bleeding events was significantly lower in the \u2264\u200930\u2010day DAPT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In HBR patients treated with BP\u2010SES, a\u2009\u2264\u200930\u2010day DAPT regimen is associated with a low rate of ischemic events and a significant reduction in major bleeding events.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p><jats:bold>Trial Registration:<\/jats:bold> PROSPERO CRD42024524208.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31481","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:04:30Z","timestamp":1741755870000},"page":"1502-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["30\u2010Day DAPT in Patients at High Bleeding Risk Undergoing PCI With Biodegradable\u2010Polymer Sirolimus\u2010Eluting Ultra\u2010Thin Stent"],"prefix":"10.1002","volume":"105","author":[{"given":"Andrea","family":"Erriquez","sequence":"first","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara Cona Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Leistner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine Goethe University Hospital Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Paradies","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maasstad Hospital Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Pavasini","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara Cona Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Serenelli","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara Cona Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Casella","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Ospedale Maggiore Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Biscaglia","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara Cona Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Naber","sequence":"additional","affiliation":[{"name":"Facharztpraxis Baldeney Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5150-188X","authenticated-orcid":false,"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara Cona Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter C.","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maasstad Hospital Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.070"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa671"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029289"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503943"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.08.074"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065448"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.123.014042"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.010312"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2020.08.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300468"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.0804"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.07.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-5683.24.06462-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw525"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108749"}],"container-title":["Catheterization 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