{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T05:40:01Z","timestamp":1749706801734,"version":"3.41.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Left atrial appendage occlusion (LAAO) has an excellent safety profile but there is growing evidence of adverse long\u2010term sequelae of peri\u2010device leak and device\u2010related thrombus. This study seeks to determine if guidance from 3D\u2010printed models of left atrial appendages reduces the incidence of side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature search was conducted in the following databases: Pubmed, Google Scholar, and Europe PMC. Cohort studies that directly compared outcomes using 3D\u2010printed model simulations before undergoing LAAO versus using conventional imaging only among patients with nonvalvular atrial fibrillation, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc scores\u2009\u2265\u20091, and relative or absolute contraindications to long\u2010term anticoagulation were included. Clinical outcomes included incidence of peri\u2010device leak, mismatch, and device\u2010related thrombus. Meta\u2010analysis was done using the random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only three cohort studies were eligible for meta\u2010analysis with a mean follow\u2010up period of 25 months. This included a total of 204 patients (mean age, 75 years). Using 3D printed models of left atrial appendage based on transesophageal echocardiogram and cardiac computed tomography had statistically significantly less incidence of peri\u2010device leak (log OR \u22122.47; 95% CI: \u22123.70 to 1.24; <jats:italic>p<\/jats:italic>\u2009=\u20090.00), incidence of mismatch (log OR \u22121.61; 95% CI: \u22122.50 to 0.73; <jats:italic>p<\/jats:italic>\u2009=\u20090.00) and shorter procedural time (mean difference \u221224.86; 95% CI: \u221231.75 and \u221227.11; <jats:italic>p<\/jats:italic>\u2009=\u20090.00). Although the incidence of device\u2010related thromboembolism was 49% less in the 3D printing\u2010guided group, the difference was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Less incidence of peri\u2010device leak and mismatch were observed with 3D printing\u2010guided left atrial appendage occlusion. A highly powered randomized controlled trial may have to be done to confirm the findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31503","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T05:20:00Z","timestamp":1743052800000},"page":"1688-1694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three\u2010Dimensional\u2010Printed Models Reduce Adverse Events of Left Atrial Appendage Occlusion: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-1887","authenticated-orcid":false,"given":"Jaeny Delos","family":"Santos","sequence":"first","affiliation":[{"name":"Our Lady of Fatima University College of Medicine Valenzuela City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis Joshua","family":"Beloy","sequence":"additional","affiliation":[{"name":"Ateneo School of Medicine and Public Health Pasig City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-182X","authenticated-orcid":false,"given":"Ralf Martz","family":"Sulague","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2984-0911","authenticated-orcid":false,"given":"Henry","family":"Okudzeto","sequence":"additional","affiliation":[{"name":"Dodowa Health Research Center Dodowa Greater Accra Region Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian Reeze","family":"Medina","sequence":"additional","affiliation":[{"name":"Manila Central University College of Medicine Caloocan City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thea Danielle","family":"Cartojano","sequence":"additional","affiliation":[{"name":"Cebu Institute of Medicine Cebu City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-6286","authenticated-orcid":false,"given":"Nikki","family":"Cruz","sequence":"additional","affiliation":[{"name":"Our Lady of Fatima University College of Medicine Valenzuela City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Daniel","family":"Mortalla","sequence":"additional","affiliation":[{"name":"Cebu Institute of Medicine Cebu City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Kpodonu","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595140"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12216909"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00970"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.02.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1188322"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.06.018"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-017-1289-6"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr488"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.02.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035090"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.03.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscai.2022.100405"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi13101575"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi14020464"}],"container-title":["Catheterization 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