{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T05:40:01Z","timestamp":1749706801313,"version":"3.41.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated left ventricular end diastolic pressure (LVEDP) following transcatheter aortic valve implantation (TAVI) has been identified as a predictor of heart failure and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine whether change in LVEDP is a more powerful predictor of adverse clinical outcomes than elevated LVEDP post\u2010TAVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent TAVI at two high volume centers between January 2013 and December 2023 were screened for inclusion. LVEDP measurements were taken before and immediately after TAVI. Hospital records were analyzed for mortality and heart failure hospitalization (HFH). Patients were stratified into those whose LVEDP decreased (post\u2010TAVI LVEDP &gt;\u20095\u2009mmHg lower), didn't change (\u00b15\u2009mmHg) or increased (post\u2010TAVI LVEDP &gt;\u20095\u2009mmHg higher).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1073 patients were included. The median follow\u2010up period was 28.9 months with 15.5% followed up for over 5 years. Increase in LVEDP was associated with increased incidence of 5\u2010year mortality (40.3% vs. 28.4% vs. 23.2%; <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001) and HFH (23.3% vs. 10.0% vs. 7.1%; <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001) compared to no change or decrease in LVEDP. On multivariate analysis, increase in LVEDP post\u2010TAVI was an independent predictor of all\u2010cause mortality and HFH. Elevated LVEDP (&gt;\u200915\u2009mmHg) alone post\u2010TAVI was predictive of HFH but not mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients in whom LVEDP increases post\u2010TAVI have a significantly higher incidence of mortality and HFH within 1 month, and this persists for at least 5\u2010years post\u2010procedure. According to our results, the change in LVEDP is a more powerful predictor of adverse clinical outcomes than elevated post\u2010TAVI LVEDP alone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31508","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T22:19:35Z","timestamp":1743200375000},"page":"1677-1687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Prognostic Implications of Change in LVEDP during TAVI"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-3919","authenticated-orcid":false,"given":"Paul","family":"Bamford","sequence":"first","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"},{"name":"University of Newcastle  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadir","family":"Elamin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northern General Hospital Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowan","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Sherwen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate V.","family":"Gatenby","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northern General Hospital Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleman","family":"Aktaa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Malkin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Cunnington","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-6130","authenticated-orcid":false,"given":"Daniel J.","family":"Blackman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noman","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"72","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto C. M.","year":"2021","journal-title":"Circulation"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14435"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"issue":"23","key":"e_1_2_11_6_1","article-title":"Impact of Left Ventricular End\u2010Diastolic Pressure As a Marker for Diastolic Dysfunction on Long\u2010Term Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement","volume":"1109","author":"Emelianova M.","year":"2023","journal-title":"Hellenic journal of cardiology : HJC = Hell\u0113nik\u0113 kardiologik\u0113 epithe\u014dr\u0113s\u0113"},{"issue":"11","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"A1288","DOI":"10.1016\/S0735-1097(18)31829-1","article-title":"Left Ventricular End\u2010Diastolic Pressure After Transcatheter Aortic Valve Replacement Is a Predictor of 30 Days Re\u2010Admission Due to Heart Failure","volume":"71","author":"Ito N.","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.01.022"},{"issue":"3","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/2632463620972215","article-title":"Asymptomatic Severe Aortic Stenosis: Early Intervention in Perspective","volume":"1","author":"Agrawal A.","year":"2020","journal-title":"Indian Journal of Clinical Cardiology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032839"},{"issue":"16","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030271","article-title":"Amyloid Transthyretin Cardiomyopathy in Elderly Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation","volume":"12","author":"Dobner S.","year":"2023","journal-title":"Journal of the American Heart Association"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx589"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.048"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.6.659"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.666016"},{"issue":"1","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12933-023-01970-w","article-title":"Left Ventricular Remodeling Response to SGLT2 Inhibitors in Heart Failure: An Updated Meta\u2010Analysis of Randomized Controlled Studies","volume":"22","author":"Carluccio E.","year":"2023","journal-title":"Cardiovascular Diabetology"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:58:55Z","timestamp":1749704335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/ccd.31508"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31508","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"2024-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}