{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:43:21Z","timestamp":1772329401374,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Impella CP is a catheter\u2010based ventricular assist device used in the management of cardiogenic shock and to support high\u2010risk percutaneous coronary interventions (PCI). Despite its growing use, the effects of Impella CP on coronary flow dynamics as measured by intracoronary continuous thermodilution have not been fully quantified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate the impact of percutaneous ventricular unloading (PVU) with Impella CP on coronary flow reserve (CFR) and microvascular resistance reserve (MRR) in patients with severe nonischemic dilated cardiomyopathy undergoing intracoronary infusion of autologous bone\u2010marrow derived mononuclear cells (BMMNCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Coronary flow (Q) was assessed using intracoronary continuous thermodilution both at rest (Qrest) and during hyperemia (Qhyper) before and after PVU with the Impella CP. Measurements were performed in the left anterior descending (LAD) artery using a dedicated pressure\/thermistor coronary guidewire. CFR and MRR were calculated post\u2010hoc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients underwent investigation with continuous thermodilution. Initiation of LV unloading with Impella CP resulted in a significant increase in CFR (from 2.72\u2009\u00b1\u20090.76, to 3.9\u2009\u00b1\u20091.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.049) and MRR (from 3.09\u2009\u00b1\u20090.97, to 4.50\u2009\u00b1\u20091.93 <jats:italic>p<\/jats:italic>\u2009=\u20090.022). A decrease in mean Qrest and an increase in mean Qhyper was also noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PVU with Impella CP led to a significant increase CFR and MRR, suggesting an improvement in coronary haemodynamic reserve. Further studies are needed to validate these findings in a larger patient population.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> Clinicaltrials. org: DCM Support NCT03572660.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31514","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T11:50:22Z","timestamp":1743076222000},"page":"1719-1722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Left Ventricular Unloading in Nonischemic Dilated Cardiomyopathy Improves Coronary Haemodynamic Reserve"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-6199","authenticated-orcid":false,"given":"Samer","family":"Fawaz","sequence":"first","affiliation":[{"name":"The Essex Cardiothoracic Centre Basildon Hospital Basildon UK"},{"name":"Anglia Ruskin School of Medicine &amp; MTRC Anglia Ruskin University Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohini","family":"Ramaseshan","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust London UK"},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarosh","family":"Khan","sequence":"additional","affiliation":[{"name":"The Essex Cardiothoracic Centre Basildon Hospital Basildon UK"},{"name":"Anglia Ruskin School of Medicine &amp; MTRC Anglia Ruskin University Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Davies","sequence":"additional","affiliation":[{"name":"The Essex Cardiothoracic Centre Basildon Hospital Basildon UK"},{"name":"Anglia Ruskin School of Medicine &amp; MTRC Anglia Ruskin University Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Collet","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, OLV Clinic Aalst Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-7629","authenticated-orcid":false,"given":"Grigoris V.","family":"Karamasis","sequence":"additional","affiliation":[{"name":"School of Medicine, Attikon University Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Cook","sequence":"additional","affiliation":[{"name":"The Essex Cardiothoracic Centre Basildon Hospital Basildon UK"},{"name":"Anglia Ruskin School of Medicine &amp; MTRC Anglia Ruskin University Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust London UK"},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust London UK"},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute Queen Mary University of London London UK"},{"name":"NIHR Barts Biomedical Research Centre Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Keeble","sequence":"additional","affiliation":[{"name":"The Essex Cardiothoracic Centre Basildon Hospital Basildon UK"},{"name":"Anglia Ruskin School of Medicine &amp; MTRC Anglia Ruskin University Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.15420\/usc.2020.18"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005870"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21160"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.12.014"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.010454"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00772"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.006194"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:59:03Z","timestamp":1749704343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/ccd.31514"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31514","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"assertion":[{"value":"2024-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}