{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:31:36Z","timestamp":1781731896570,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Guideline\u2010recommended PARIS thrombotic risk score predicts coronary thrombosis events (CTE) in Acute Coronary Syndrome (ACS) patients undergoing Percutaneous Coronary Intervention. We aim to evaluate whether D\u2010dimer, a thrombotic biomarker, can predict long\u2010term adverse events and improve the prognostic value of PARIS score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      This is a post\u2010hoc analysis on a prospective cohort of 10,724 Chinese patients undergoing PCI. Patients who presented as ACS were included and stratified according to baseline D\u2010dimer level (cutoff 0.28\u2009\u00b5g\/mL). The primary endpoint is all\u2010cause death. Secondary endpoints are cardiac death and CTE. A total of 5139 ACS patients with PCI were analyzed, 2735 patients had D\u2010dimer\u2009\u2265\u20090.28\u2009\u00b5g\/mL, while 2404 patients had D\u2010dimer\u2009&lt;\u20090.28\u2009\u00b5g\/mL. After adjusting for confounders, patients with higher D\u2010dimer had significantly higher risk of 5\u2010year all\u2010cause death (HR\u2009=\u20091.951, 95% CI: 1.366\u20132.787) and cardiac death (HR\u2009=\u20092.513, 95% CI: 1.574\u20134.012), whilst a trend toward higher risk of 5\u2010year CTE (HR\u2009=\u20091.285, 95% CI: 0.956\u20131.729) was observed. Compared with PARIS score alone, adding D\u2010dimer to the model increased the area under the receiver operating characteristic curve on 5\u2010year all\u2010cause death (0.663\u20130.701,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and cardiac death (0.652\u20130.699,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), both with significant net reclassification improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our cohort of ACS patients undergoing PCI, D\u2010dimer independently predicts long\u2010term all\u2010cause death and cardiac death, and improves the predictive value of PARIS score over 5\u2010year all\u2010cause death and cardiac death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31526","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:16:22Z","timestamp":1744089382000},"page":"144-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of D\u2010Dimer on the Prognostic Value of PARIS Thrombosis Risk Score in Acute Coronary Syndrome Patients Undergoing PCI: From a Large Prospective Cohort Study"],"prefix":"10.1002","volume":"106","author":[{"given":"Sida","family":"Jia","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, Fuwai hospital Chinese Academy of Medical Sciences Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshan","family":"Yuan","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, Fuwai hospital Chinese 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